基本信息
views: 45
Career Trajectory
Bio
1997-2001 B.Sc. in Chemistry, Fudan University
2001-2005 Ph.D. in Biochemistry, Hong Kong University of Science and Technology (HKUST)
2005-2007 Postdoctoral Research Associate, Department of Biochemistry, HKUST
2007-2009 Research Assistant Professor, Department of Biochemistry, HKUST
2009- Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences
Research Interests
On the basis of NMR spectroscopy and X-ray crystallography, we focus on the structural and functional studies of protein complexes that are involved in the control of the cell polarity and molecular motors that play prominent roles in regulating intracellular transport.
1. Structural dissection of protein complexes involved in the control of cell polarity
Polarization of cells is a fundamental process vital for a variety of biological activities such as embryonic asymmetric cell division, epithelial differentiation, neuronal development, and cancer cell migration. Both establishment and maintenance of cell polarity are complicated processes and rigorously regulated by a number of protein complexes. These protein complexes are evolutionally conserved and restrictedly distributed at the specific cell cortex acting as hallmarks of cellular polarization. We focus on the structural and functional dissection of these protein complexes, and aim to investigate how these protein complexes assemble and what’s the biological significance for regulating cell polarity. The results of our research will provide mechanistic insights into the organization of cell polarity-regulatory protein complexes and may also hopefully generalize some rules for the establishment and maintenance of cell polarity.
2. Structural basis for molecular motor-mediated intracellular transport
Intracellular transport is a fundamental biological process responsible for delivering, exchanging, and recycling of biological materials within cells. Dysfunction of this process is coupled with a large number of pathological diseases. Molecular motors are cytoskeleton-based biological molecular machines capable of carrying cargo vesicles and walking along the cytoskeletons, and thus function as core components for intracellular transport. We work on the structural and functional studies of molecular motors, and are mainly interested in how the activity of molecular motors is exquisitely regulated in terms of the monomer-dimer conversion and the motor activation-inactivation. Our overall research will provide the molecular mechanism for the motor regulation and may also shed some light on molecular motor-mediated intracellular transport.
Research Interests
Papers共 156 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF INTERNATIONAL MEDICAL RESEARCHno. 2 (2024): 3000605241234050-3000605241234050
Virusesno. 4 (2024): 541
Letao Li, Xilu Liu, Shanshan Yang,Meijiao Li,Yanwei Wu,Siqi Hu, Wenjuan Wang,Amin Jiang,Qianqian Zhang, Junbing Zhang, Xiaoli Ma,Junyan Hu,
Natureno. 8008 (2024): 1-9
Journal of International Medical Researchno. 2 (2024): 3000605241234050-3000605241234050
Biosensors and Bioelectronics (2024): 116429-116429
Angewandte Chemie (International ed. in English)no. 22 (2024): e202404069-e202404069
Bingrong Wu,Xiaoning Jiang,Dalin He,Feng Wei, Mingtian Mao, Yudong Zhu, Hong Su,Yi Tang,Youxiang Diao
AVIAN PATHOLOGYno. 3 (2024): 155-163
BMC Veterinary Researchno. 1 (2023): 1-7
TRANSBOUNDARY AND EMERGING DISEASES (2023): 1-5
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