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个人简介
Our research group is interested in understanding cardiac remodeling in genetic and acquired cardiomyopathies. We are working on novel therapies to improve cardiac function including use of the naturally occurring small molecule 2-deoxyadenosine triphosphate (dATP). We have shown that dATP increases contraction in human end-stage heart failure and that a gene therapy approach to raise its levels improves cardiac function in rodent models. We have pioneered an method to measure all dNTPs, including dATP at femtomole level using HPLC-MS/MS. I currently run an independent laboratory focused on better understanding of mechanisms of cardiomyopathies and working towards novel therapies that work at the level of the sarcomere. My area of expertise is rodent echocardiography, cardiac physiology and muscle mechanics. The assays used in the lab span from isolated myosin motors to myofibrils, multicellular preparation, cells and whole organ analysis. We are also using computational modeling techniques to study Sarcomeric variants and response to therapies.
研究兴趣
论文共 66 篇作者统计合作学者相似作者
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Nature Computational Scienceno. 3 (2024): 224-236
Ketaki N Mhatre,Julie Mathieu,Amy Martinson,Galina Flint, Leslie P Blakley, Arash Tabesh,Hans Reinecke,Xiulan Yang,Xuan Guan,Eesha Murali,Jordan M Klaiman,Guy L Odom,
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bioRxiv the preprint server for biology (2023)
Stephanie Neys,Kristina Kooiker,Amy Martinson,Darren Hwee,James Hartman, Anne N. Murphy,Bradley Morgan,Jennifer Davis,Fady Malik,Farid Moussavi-Harami
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