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Adult tissue specific stem cells play a critical role in replacing lost tissue, they do not act in isolation and multiple other cell types modulate their function. This ensures that the rebuilding of functional, stromal, vascular and other tissue components is coordinated and follows a temporal and spatial organization compatible with function. Our goal is to identify and characterize these “accessory” cells types as a starting point to understand how they regulate tissue specific stem cells as well as each other, and how such regulation goes awry in pathological situations. In particular, we have focused our attention on the role of innate immune cells and stromal progenitors. In this context our lab works on three research directions, cellular systems in muscle regeneration, microglia/macrophages in CNS pathology and epigenetic control of lineage choice/differentiation.
Adult tissue specific stem cells play a critical role in replacing lost tissue, they do not act in isolation and multiple other cell types modulate their function. This ensures that the rebuilding of functional, stromal, vascular and other tissue components is coordinated and follows a temporal and spatial organization compatible with function. Our goal is to identify and characterize these “accessory” cells types as a starting point to understand how they regulate tissue specific stem cells as well as each other, and how such regulation goes awry in pathological situations. In particular, we have focused our attention on the role of innate immune cells and stromal progenitors. In this context our lab works on three research directions, cellular systems in muscle regeneration, microglia/macrophages in CNS pathology and epigenetic control of lineage choice/differentiation.
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PM & R : the journal of injury, function, and rehabilitation (2024)
Free Neuropathology (2024)
Laura N Stankiewicz,Fabio MV Rossi,Peter W Zandstra,Kevin Salim, Emily A Flaschner,Yu Xin Wang,John M Edgar, Bruce ZB Lin,Grace C Bingham, Matthew C Major,Ross D Jones,Helen Blau,
bioRxiv : the preprint server for biology (2023)
STAR PROTOCOLSno. 4 (2023): 102638-102638
Elena Groppa,Paolo Martini, Nima Derakhshan,Marine Theret,Morten Ritso,Lin Wei Tung,Yu Xin Wang,Hesham Soliman,Mark Stephen Hamer,Laura Stankiewicz, Christine Eisner, Le Nevé Erwan,
Cell reportsno. 2 (2023): 112051-112051
Nature communicationsno. 1 (2023): 8498-8498
Mehwish Anwer, Angela Zhang,Brianna Bristow,Jeffrey LeDue, Zefang Wang,Sarah Wang,Larissa Kraus,Wai Hang Cheng,Kurt A. McInnes,Jianjia Fan,Honor Cheung,Carlos Barron,
JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A55-A55
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