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The Atomic & Mass Spectrometry – A&MS research unit is specialized in the determination, speciation and isotopic analysis of (trace) elements using various forms of ICP-mass spectrometry (ICP-MS). The research unit studies fundamental issues of the technique and develops novel analytical methods to address challenging problems in an interdisciplinary context. In the context of cancer-related research, the A&MS unit, e.g., develops analytical approaches to visualize the 2-dimensional and 3-dimensional distribution of elements (e.g., Pt under the form of a chemotherapeutic drug) in tissues based on the combination of laser ablation (LA) sampling and ICP-MS. LA-ICP-MS can, e.g., also be used to study the fate of Fe-containing nanoparticle drug carriers or to study the distribution of metal-tagged antibodies in a tissue sample. The A&MS unit is also pioneering in exploring the use of isotope ratios in human body fluids and tissues as a marker, e.g., for iron status or liver disease. A difference was established in the isotopic composition of Cu between tumor tissue and adjacent healthy tissue. Analytical protocols were developed for high-precision isotopic analysis of a series of essential elements (e.g., Mg, Ca, Fe, Cu, Zn) using multi-collector ICP-MS. Efforts are made to unravel the factors governing the isotopic composition of selected elements in human body fluids and tissues. In the contexts described above, the A&MS unit is cooperating with several departments of the Ghent University Hospital, the Leiden University Medical Centre, the Mayo Clinic (US) and the Japanese National Center for Global Health and Medicine. The group is also developing methods for single-cell analysis whereby the concentrations of metals, metalloids and some non-metals can be quantified on a single-cell basis.
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ANALYTICA CHIMICA ACTA (2024): 342089-342089
Talanta (2024): 126210-126210
JOURNAL OF ARCHAEOLOGICAL SCIENCE-REPORTS (2024)
Marco Grotti,Francisco Ardini, Maria Alessia Vecchio, Matilde Mataloni,Stefano Bertinetti,Federica Bruschi,Beatrice Moroni,David Cappelletti,Kasper Hobin,Frank Vanhaecke
Journal of Archaeological Science: Reports (2024): 104344
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Quaternary Science Reviews (2024): 108564
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRYno. 4 (2024)
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRYno. 3 (2024): 888-899
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