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个人简介
Dr. Symmans’ defining contributions to the field of breast cancer include an improved method to measure pathologic response, and the development of genomic assays to predict both response and survival following neoadjuvant chemotherapy. Within 5 years of initial publication, the residual cancer burden (RCB) method of pathologic evaluation has become a standard secondary or primary response endpoint in clinical trials (e.g. the online RCB calculator website had 17,000 visits in 2011). RCB has also formed a basis for training more effective chemopredictive genomic assays that consider primary resistance separately from excellent response, and for understanding the sequential synergy that can be achieved with chemo-endocrine therapy for Stage II-III breast cancer. These findings are re-shaping the approach to development of “omics-based” predictive tests. In parallel, he has advanced the practical application of minimally invasive breast biopsy techniques for translational research through evidence-based studies of biospecimen yield and quality.
研究兴趣
论文共 762 篇作者统计合作学者相似作者
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Chowdhury Arif Jahangir,David B. Page,Glenn Broeckx, Claudia A. Gonzalez,Caoimbhe Burke, Clodagh Murphy,Jorge S. Reis-Filho,Amy Ly,Paul W. Harms,Rajarsi R. Gupta,Michael Vieth,Akira Hida,
JOURNAL OF PATHOLOGYno. 3 (2024): 271-288
crossref(2024)
Cancer Researchno. 6_Supplement (2024): 1207-1207
Cancer Researchno. 9_Supplement (2024): GS03-07
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 729-740
crossref(2024)
Journal of Clinical Oncologyno. 16_suppl (2024): 565-565
Histopathology (2024)
crossref(2024)
Journal of Clinical Oncologyno. 16_suppl (2024): 538-538
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作者统计
#Papers: 758
#Citation: 45409
H-Index: 98
G-Index: 206
Sociability: 8
Diversity: 3
Activity: 246
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