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个人简介
Our group is interested in understanding how the architecture of the genome contributes to the specificity and robustness of the gene expression programs that govern embryonic development and cell differentiation.
Vertebrate genomes contain hundreds of thousands of regulatory sequences that can influence the expression of genes sometimes located hundreds of kilobases away. Our main goal is to understand how the folding of the genome in specific domains and dynamic structures contributes to transform such a dispersed information into highly specific regulatory ensembles. We study as well how perturbations of these processes, notably due to chromosomal rearrangements, could lead to developmental or oncogenic pathologies, but may have also participated to animal evolution.
Vertebrate genomes contain hundreds of thousands of regulatory sequences that can influence the expression of genes sometimes located hundreds of kilobases away. Our main goal is to understand how the folding of the genome in specific domains and dynamic structures contributes to transform such a dispersed information into highly specific regulatory ensembles. We study as well how perturbations of these processes, notably due to chromosomal rearrangements, could lead to developmental or oncogenic pathologies, but may have also participated to animal evolution.
研究兴趣
论文共 80 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2024): 3931-3931
Anqi Yu,Ali E Yesilkanal,Ashish Thakur,Fan Wang,Yang Yang, William Phillips,Xiaoyang Wu,Alexander Muir,Xin He,Francois Spitz,Lixing Yang
Nucleic acids research (2024)
An Yu, Ali E. Yesilkanal,Ashish Thakur,Fan Wang,Xiaoyang Wu,Alexander Muir,Xin He,François Spitz,Lixing Yang
Cancer researchno. 7_Supplement (2023): 3136-3136
Current opinion in genetics & development (2023): 102064-102064
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Nature Communications (2021)
PLOS BIOLOGYno. 11 (2020): 1-48
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作者统计
#Papers: 79
#Citation: 8718
H-Index: 33
G-Index: 59
Sociability: 6
Diversity: 3
Activity: 22
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