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Bio
His research program is a combination of laboratory research on human lipoprotein metabolism, and clinical trials in nutrition and cardiovascular disease. The laboratory research concerns the acute and long-term effects of diet on the function of lipoproteins including VLDL, LDL and HDL in humans; and biochemical epidemiology of lipoprotein particle types and CVD. His laboratory is studying HDL speciation based on content of specific proteins, and recently discovered that a type of HDL that contains apolipoprotein C-III predicted higher rates of heart disease, the opposite to the protective relation for the total HDL.Dr. Sacks was Chair of the Design Committee of the DASH study where the DASH diet was designed, and Chair of the Steering Committee for the DASH-Sodium trial. These multi-center National Heart Lung and Blood Institute trials found major beneficial additive effects of low salt and a dietary pattern rich in fruits and vegetables on blood pressure. Dr. Sacks was Co-Chair of the OmniHeart Trial, a multicenter feeding trial that found that a variation of the DASH diet that is higher in protein or unsaturated fat diets further improved blood pressure and lipid risk factors compared to the lower fat DASH-type diet. Dr. Sacks was Principal Investigator of an NIH funded trial on dietary approaches for weight loss and maintenance, the PoundsLost trial. In this trial, 4 diets varying in protein, carbohydrate and fat content were tested in 811 overweight people for 2 years. The diets had the same beneficial effects on weight loss, and all favorably affected risk factors for cardiovascular disease. Dr. Sacks is principal investigator of a new trial that is evaluating the effect of carbohydrate, type and amount, on insulin resistance and cardiovascular risk factors. Dr. Sacks published a clinical review on dietary treatment of hypertension in New England Journal of Medicine. This review emphasized that optimizing diet quality, including sodium reduction, can eliminate the age-related rise in blood pressure with age in just 4 weeks, as shown in new analyses in the DASH-Sodium trial.
Research Interests
Papers共 812 篇Author StatisticsCo-AuthorSimilar Experts
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Gastroenterologyno. 5 (2024): S-1186-S-1187
Circulationno. Suppl_1 (2024)
The American journal of clinical nutritionno. 5 (2024): 1293-1300
Qisi Yao, Carolina D de Araujo,Filippa Juul,Catherine M Champagne,George A Bray,Frank M Sacks,Maya K Vadiveloo
Obesity (Silver Spring, Md.)no. 7 (2024): 1281-1289
Journal of the American College of Cardiology (2024)
Diabetologiano. 3 (2024): 506-515
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYno. 2 (2024): 435-451
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