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Dr. Rosenberg’s research program focuses on inflammation and specifically highlights the inflammatory responses elicited by acute respiratory virus infection. While therapeutic developments in this field have focused on the development of new and ever more complex antiviral agents, Dr. Rosenberg and her group have shown that virus-induced inflammation that is insensitive to these agents contributes profoundly to airway dysfunction and death. Her studies include natural mouse pathogen models, most notably, pneumonia virus of mice (PVM; family Pneumoviridae). Via an ongoing exploration of lethal PVM infection, her group has defined the inflammatory responses that are characteristic of natural respiratory virus infections in vivo. They have also shown that manipulation of the inflammatory response can convert a lethal infection into one that is functionally benign.
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