His work focused on the development of monoclonal antibody-based strategies for the treatment of melanoma and epithelial cancers. Alongside J. Mendelsohn, he led the fi rst clinical trial with anti-EGFR monoclonal antibodies in humans.

Paco has made important contributions in the cell/molecular biology of pancreatic and bladder cancer and, most recently, the genetic analysis of benign epidermal tumours. He has served on the Advisory Editorial Boards of Biochemical Journal (1994-2008) and the Council of the European Pancreatic Club (2005-2008). He has served as President of the Spanish Association for Cancer Research (ASEICA) (2002-2004) and received several awards including the Charles Mérieux Chair at the Ecole Normale Supérieure in Lyon, France (1997).