基本信息
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职业迁徙
个人简介
I am a Ramon y Cajal & Ikerbasque Research Fellow at Achucarro Basque Center for Neuroscience. We study how neurodegeneration alters the brain extracellular matrix, and how this process affects tissue homeostasis. We also explore matrix manipulation as a disease-modifying strategy, either by increasing clearance through the extracellular space or by modulating glial physiology using the matrix as a signal. We mostly use in vivo, ex vivo and 3D-in vitro models and fluorescence microscopy.
PhD in Neurosciences in 2013 (Universidad del País Vasco, Spain), my doctoral thesis in the team of Dr. Carlos Matute studied glutamate homeostasis in animal models of brain ischemia and multiple sclerosis. During my postdoctoral journey (2014-2018) at the team of Dr. Erwan Bezard in Bordeaux, I developed super-resolution approaches to analyze the extracellular compartment in animal models of Parkinson’s disease. These results unraveled the nanoscale organization of the extracellular space in the parkinsonian brain and described an unknown feedback loop between the extracellular matrix and microglia in pathology. This work, and the tools developed here, set the founding stone for my current research at Achucarro, focused on the glia-matrix interplay in healthy, aging and pathological brain.
研究兴趣
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GLIA (2023): E666-E666
A. Montilla, I. Calvo, G. P. Mata,S. Kooistra,O. Fresnedo, M. Koster,A. Sierra,F. N. Soria,B. Eggen,V. Tepavcevic,J. A. Fernandez, C. Matute,
GLIA (2023): E955-E955
Alejandro Montilla,Alazne Zabala, Ibai Calvo, Paloma Mata, Irene Tomé,Mirjam Koster,Amanda Sierra,Susanne M. Kooistra,Federico Nicolás Soria,Bart J.L. Eggen,Olatz Fresnedo,José Andrés Fernández,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sol Beccari,Virginia Sierra-Torre,Jorge Valero, Marta Pereira-Iglesias, Mikel Garcia-Zaballa,Federico N. Soria,Laura De Las Heras-garcia,Alejandro Carretero-Guillen,Estibaliz Capetillo-Zarate,Maria Domercq,Paloma R. Huguet,David Ramonet,
Cell reportsno. 8 (2023): 112950-112950
IBRO Neuroscience Reports (2023): S260-S260
A. Plaza-Zabala,V. Sierra-Torre, J. Valero,M. Pereira-Iglesias, M. Garcia-Zaballa,F. N. Soria,L. de las Heras-Garcia, A. Carretero-Guillen,E. Capetillo-Zarate,M. Domercq,P. R. Huguet,T. E. Faust,
GLIA (2023): E660-E660
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