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Research & Clinical Interests
Dr. Leenen’s team was involved in two types of human research: mechanistic and therapeutic.
Mechanistic Studies
When the heart is damaged, it often becomes enlarged and is unable to pump the amount of blood the body needs, resulting in water retention, shortness of breath and fatigue. The sympathetic nervous system regulates heart function, and plays an important role in heart failure. By comparing medications or different doses of medications used to treat heart failure, Dr. Leenen’s unit researched the effect medications have on the sympathetic nervous system and the function of the heart. His team also researched the role certain hormones play in the progression of heart failure by comparing hormone levels in the heart itself.
Therapeutic Studies
A large part of Dr. Leenen’s research dealt with evaluating existing medications and the effect they have on the sympathetic nervous system, blood pressure and heart. His team participated in the ALLHAT trial: the largest study ever done in people with high blood pressure. Over 600 clinics in Canada and the United States participated, enrolling more than 42,000 volunteers.
研究兴趣
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Canadian Journal of Cardiologyno. 10 (2021)
Madhura Thipse,Winnie N. Ye, Maleka Ben Mahdi, Sharlin Azad,Ross Davies,Marc Ruel,Marc A. Silver,Lale Hakami,Thierry Mesana,Frans Leenen,Tofy Mussivand
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