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Dendritic Cell and Macrophage Ontogeny
Dendritic cells (DCs), monocytes and macrophages play crucial and distinct roles in tissue homeostasis and immunity, but also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies aiming at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis.
The focus of the laboratory is to understand the ontogeny of DCs, monocytes and macrophages, their differentiation pathways and how their unique ontogeny dictates their immune functions.
Our approach encompasses the integration of high dimensional platforms such as RNAseq, single cell transcriptome analysis using microfluidic RNA sequencing and deep immunophenotypic assessment using state of the art 18 parameters flow cytometry or Cytometry by Time-Of-Flight mass spectrometry (CyTOF) (In collaboration with Dr Evan Newell, SIgN). Such high density molecular profiling at the single level and at unprecedented dimensionality and complexity will provide new insights in the biology of DC, monocyte and macrophage cell populations. Defining macrophage and DC populations on the criteria of their origin may aid our understanding of their discrete roles in tissue immunity and homeostasis, as ontogeny of DC and macrophage subsets likely underlie their functional specializations.
Dendritic Cell and Macrophage Ontogeny
Dendritic cells (DCs), monocytes and macrophages play crucial and distinct roles in tissue homeostasis and immunity, but also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies aiming at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis.
The focus of the laboratory is to understand the ontogeny of DCs, monocytes and macrophages, their differentiation pathways and how their unique ontogeny dictates their immune functions.
Our approach encompasses the integration of high dimensional platforms such as RNAseq, single cell transcriptome analysis using microfluidic RNA sequencing and deep immunophenotypic assessment using state of the art 18 parameters flow cytometry or Cytometry by Time-Of-Flight mass spectrometry (CyTOF) (In collaboration with Dr Evan Newell, SIgN). Such high density molecular profiling at the single level and at unprecedented dimensionality and complexity will provide new insights in the biology of DC, monocyte and macrophage cell populations. Defining macrophage and DC populations on the criteria of their origin may aid our understanding of their discrete roles in tissue immunity and homeostasis, as ontogeny of DC and macrophage subsets likely underlie their functional specializations.
Research Interests
Papers共 509 篇Author StatisticsCo-AuthorSimilar Experts
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Anna Vyhlídalová Kotrbová,Kristína Gömöryová,Antónia Mikulová,Hana Plešingerová, Stanislava Sladeček,Marek Kravec, Šárka Hrachovinová,David Potěšil,Garett Dunsmore,Camille Blériot,Mathilde Bied,Jan Kotouček,
Journal of extracellular vesiclesno. 3 (2024): e12420-e12420
H. Theobald, D. A. Bejarano, N. Katzmarski, J. Haub,J. Schulte-Schrepping,J. Yu,K. Bassler, A. L. Ament,C. Osei-Sarpong, F. Piattini, L. Vornholz, W. T'Jonck,
NATURE IMMUNOLOGY (2024)
Immunityno. 7 (2024): 1567-1585.e5
Nature Communicationsno. 1 (2024): 1-12
Henna Lehtonen,Heli Jokela, Julian Hofmann, Lauriina Tola,Arfa Mehmood,Florent Ginhoux,Burkhard Becher,Melanie Greter,Marko Salmi,Heidi Gerke,Pia Rantakari
biorxiv(2024)
Ziyi Li,Rhea Pai,Saurabh Gupta,Jennifer Currenti,Wei Guo, Anna Di Bartolomeo,Hao Feng,Zijie Zhang,Zhizhen Li,Longqi Liu, Abhishek Singh,Yinqi Bai,
Nature Cancerno. 1 (2024): 167-186
The Journal of experimental medicineno. 2 (2024)
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