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RESEARCH:
Mechanisms and animal models of acquired epilepsy
Our research group has traditionally investigated broad questions concerning mechanisms of neuronal communication in the mammalian brain; however, over the last decade, we have focused on the problem of how brain injuries lead to acquired epilepsy (i.e., epileptogenesis). We have developed or modified different animal models (i.e., status epilepticus, perinatal stroke and traumatic brain injury) to better allow us to investigate how these types of brain insult cause – after a latent period – spontaneous recurrent seizures, which is the hallmark of chronic epilepsy. Most of our research involves the hippocampus and/or neocortex, but we have studied numerous areas of the mammalian brain. We use a wide range of methods, with an emphasis on anatomic and electrophysiological techniques in the brain slice preparation and in freely behaving animals. Our group has extensive experience with radiotelemetry, and we have developed new methods for miniature wireless telemetry. These latter techniques have facilitated our research with animal models of pediatric epilepsy. Our goal is to understand the mechanisms that underlie acute and chronic seizure generation, so that we can develop new therapies for epilepsy.
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Rehan Raiyyani,Elizabeth Duquette, Hannah Culbertson, Mitchell Couldwell,Andrew Zayachkivsky,F. Edward Dudek,Kevin Staley
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Neuroscience (2021): 143-158
Bryan S Barker,Jay Spampanato,Hilary S McCarren, Melissa Smolik,Cecelia E Jackson, Eden N Hornung,David T Yeung,F Edward Dudek,John H McDonough
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