基本信息
views: 0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
The roles of ribosome biogenesis and telomere maintenance in the pathogenesis of oral cancer are poorly understood. The dyskeratosis congenita 1 gene (DKC1) has important roles in both of these molecular pathways. While germline mutations in DKC1 may precipitate cancer development, in the vast majority of individuals with sporadic cancers, the gene is not mutated. Instead, DKC1 is frequently upregulated. We have recently shown that DKC1 is a direct transcriptional target of the c-MYC oncoprotein. c-MYC is one of the most important cellular proteins; it directly and indirectly regulates many of our most fundamental biological functions. Upregulation of c-MYC has been implicated in the pathogenesis of several different cancer types, including oral cancer. We are currently investigating the role of DKC1 in influencing some of these c-MYC-related functions, including cellular proliferation, genomic stability and cellular transformation.
Research Interests
Papers共 139 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Eun Kyung Ko,Amy Anderson, Carina D'souza,Jonathan Zou,Sijia Huang,Sohyun Cho,Faizan Alawi,Stephen Prouty,Vivian Lee,Sora Yoon,Keegan Krick, Yoko Horiuchi,
Developmental cellno. 2 (2024): 187-198.e7
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyno. 3 (2023): 313-315
Oral surgery, oral medicine, oral pathology and oral radiologyno. 4 (2023): 321-322
Research squareno. 1 (2023): 6087-16
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyno. 6 (2023): e143-e147
Hannah A Liss, Yu Wang,Reza Hakim Shoushtari,Dennis Sourvanos,Faizan Alawi,Joseph P Fiorellini,Jonathan Korostoff
The International journal of periodontics & restorative dentistryno. 7 (2023): s195-s204
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn