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KEYWORDS
cancer, metastasis, melanoma
SUMMARY
For most cancer types, metastatic spread of tumor cells from a primary location to distal organs throughout the body is the pivotal determinant of poor outcomes for patients. Roughly 90% of cancer deaths are attributable to metastasis, yet our understanding of the mechanisms responsible for metastatic spread is limited. Melanoma is an excellent model to investigate the mechanistic bases of metastasis. Unlike other cancers, melanoma metastasis frequently occurs from tiny primary tumors that are measured in millimeters, reflective of melanoma’s highly aggressive nature. However, the cellular and molecular mechanisms responsible for this phenotype are incompletely understood.
KEYWORDS
cancer, metastasis, melanoma
SUMMARY
For most cancer types, metastatic spread of tumor cells from a primary location to distal organs throughout the body is the pivotal determinant of poor outcomes for patients. Roughly 90% of cancer deaths are attributable to metastasis, yet our understanding of the mechanisms responsible for metastatic spread is limited. Melanoma is an excellent model to investigate the mechanistic bases of metastasis. Unlike other cancers, melanoma metastasis frequently occurs from tiny primary tumors that are measured in millimeters, reflective of melanoma’s highly aggressive nature. However, the cellular and molecular mechanisms responsible for this phenotype are incompletely understood.
研究兴趣
论文共 179 篇作者统计合作学者相似作者
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Irene Soler-Saez,Alcida Karz, Marta R Hidalgo, Borja Gomez-Cabañes,Adolfo Lopez-Cerdan,Jose F Català-Senent, Maria de la Iglesia-Vaya,Eva Hernando,Francisco Garcia-Garcia
biorxiv(2024)
Praveen Agrawal,Shuhui Chen, Ana de Pablos,Faezeh Jame-Chenarboo, Eleazar Miera Saenz de Vega,Farbod Darvishian,Iman Osman,Amaia Lujambio,Lara K. Mahal,Eva Hernando
biorxiv(2024)
crossref(2023)
Pietro Berico,Maguelone Nogaret,Max Cigrang, Antonin Lallement, Fatemeh Vand-Rajabpour, Amanda Flores-Yanke,Giovann Gambi,Guillaume Davidson, Leane Seno,Julian Obid,Bujamin H. Vokshi,Stephanie Le Gras,
CELL REPORTSno. 11 (2023): 113363-113363
Alcida Karz,Nicolas Coudray, Erol Bayraktar,Kristyn Galbraith,George Jour, Arman Alberto Sorin Shadaloey,Nicole Eskow,Andrey Rubanov, Maya Navarro,Rana Moubarak,Gillian Baptiste,Grace Levinson,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cancer Researchno. 7_Supplement (2023): 396-396
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Melanoma researchno. 3 (2023): 163-172
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