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Bio
Principal Research Interests
Comparative and evolutionary genomics: comparison of prokaryotic and eukaryotic genomes with the aim of predicting gene functions, constructing evolutionary scenarios for particular gene families and functional categories, and deciphering general evolutionary trends. An evolutionary phenomenon we are particularly interested in is horizontal gene transfer between diverse organisms. One of the important outcomes of research in this area is the system of Clusters of Orthologous Genes (COGs).
Discovery of new viruses in metagenomes and metatranscriptomes.
Evolution of the virosphere and hierarchical taxonomy of viruses.
Virus-host coevolution and evolution of antivirus defense systems in prokaryotes and eukaryotes.
Microevolution of pathogenic viruses, in particular, during epidemics, including COVID-19.
Evolutionary regimes of human cancers,
Exploitation of genome comparisons, particularly, those between relatively close genomes, for addressing fundamental issues of evolutionary biology such as the nature and intensity of adaptation and selection in different categories of genes and different organismal lineages.
General physical principles of evolution; origin and evolution of complexity; evolution as learning; thermodynamics of evolution.
Comparative and evolutionary genomics: comparison of prokaryotic and eukaryotic genomes with the aim of predicting gene functions, constructing evolutionary scenarios for particular gene families and functional categories, and deciphering general evolutionary trends. An evolutionary phenomenon we are particularly interested in is horizontal gene transfer between diverse organisms. One of the important outcomes of research in this area is the system of Clusters of Orthologous Genes (COGs).
Discovery of new viruses in metagenomes and metatranscriptomes.
Evolution of the virosphere and hierarchical taxonomy of viruses.
Virus-host coevolution and evolution of antivirus defense systems in prokaryotes and eukaryotes.
Microevolution of pathogenic viruses, in particular, during epidemics, including COVID-19.
Evolutionary regimes of human cancers,
Exploitation of genome comparisons, particularly, those between relatively close genomes, for addressing fundamental issues of evolutionary biology such as the nature and intensity of adaptation and selection in different categories of genes and different organismal lineages.
General physical principles of evolution; origin and evolution of complexity; evolution as learning; thermodynamics of evolution.
Research Interests
Papers共 1247 篇Author StatisticsCo-AuthorSimilar Experts
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MBIOno. 2 (2024): e0309223-e0309223
Nature communicationsno. 1 (2024): 3699-3699
bioRxiv : the preprint server for biology (2024)
Science advancesno. 17 (2024): eadl0164-eadl0164
bioRxiv : the preprint server for biology (2024)
NATURE COMMUNICATIONSno. 1 (2024)
The Journal of general virologyno. 2 (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 23 (2024): e2405771121-e2405771121
Yi Wu,Sofya K Garushyants, Anne van den Hurk,Cristian Aparicio-Maldonado,Simran Krishnakant Kushwaha, Claire M King,Yaqing Ou,Thomas C Todeschini,Martha R J Clokie,Andrew D Millard,Yilmaz Emre Gençay,Eugene V Koonin,
Cell host & microbeno. 4 (2024): 557-572.e6
ISME JOURNALno. 1 (2024)
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