基本信息
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Bio
Dr. Appella was among the first researchers to identify the tumor suppressor protein p53, and he has studied its roles in the cell and regulation by post-translational modification. He and his colleagues further identified a critical phosphatase that is upregulated by p53 following DNA damage. This phosphatase, Wip1 (PPM1D), is amplified or overexpressed in several human tumors. Dr. Appella’s research currently is focused on exploring the roles of Wip1 in cells and its contribution to tumorigenesis. They additionally are exploring how Wip1 is regulated. Finally, Dr. Appella’s laboratory is working to develop specific inhibitors of Wip1 that could be advanced to the clinic
Research Interests
Papers共 536 篇Author StatisticsCo-AuthorSimilar Experts
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Jay Prakash Kumar,Dalibor Kosek, Stewart R. Durell,Lisa M. Miller Jenkins,Subrata Debnath,Nathan P. Coussens, Matthew D. Hall,Daniel H. Appella,Fred Dyda, Sharlyn J. Mazur,Ettore Appella
The Journal of biological chemistryno. 8 (2024): 107561-107561
NATURE MICROBIOLOGYno. 8 (2023): 1600-1600
crossref(2023)
Nature microbiologyno. 5 (2023): 905-918
Junya Wada, Udumbara Rathnayake,Lisa Jenkins,Moosa Mohammadi,Ettore Appella,Paul Randazzo,Lawrence Samelson
Journal of Biological Chemistryno. 3 (2023): 104316-S718
crossref(2023)
Nature Microbiologyno. 8 (2023): 1600-1600
crossref(2023)
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Author Statistics
#Papers: 533
#Citation: 61016
H-Index: 127
G-Index: 237
Sociability: 8
Diversity: 3
Activity: 4
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