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个人简介
Dr. Hay’s research uses computational models of cortical circuits to study the cellular and circuit mechanisms of cortical processing in health and disease. We are currently studying inhibition in cortical circuits in depression. In particular, we study the inhibitory synaptic connections between dendritic-targeting (somatostatin) interneurons and pyramidal neurons. We develop models of human cortical circuits by capitalizing on unique data from CAMH and Toronto Western Hospital, and study how reduced inhibition in depression affects cortical processing and oscillatory activity between cortical layers. In turn, we simulate electrode probes to characterize the signatures of the cellular effects in clinically-relevant neural signals, e.g. local field potentials and electroencephalography. In addition, we use our computational platform to test in silico the effects of candidate pharmacology for depression developed at CAMH on human and rodent model circuits. Our research integrates unique human data to develop a computational platform to advance our understanding of cellular and circuit mechanisms of brain disorders, improve the ability to diagnose using brain recordings, and facilitate the translation of candidate therapeutics by testing in silico their effects on cortical circuits.
研究兴趣
论文共 15 篇作者统计合作学者相似作者
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引用量
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期刊级别
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biorxiv(2024)
PLoS computational biologyno. 4 (2023)
Derek Howard,Homeira Moradi Chameh,Alexandre Guet-McCreight, Huan Allen Hsiao, Maggie Vuong, Young Seok Seo,Prajay Shah,Anukrati Nigam,Yuxiao Chen,Melanie Davie,Etay Hay,Taufik A Valiante,
Cell Reportsno. 2 (2021): 110232-110232
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作者统计
#Papers: 15
#Citation: 415
H-Index: 7
G-Index: 9
Sociability: 4
Diversity: 1
Activity: 3
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