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Midbrain dopaminergic neuron development
Characterizing the molecular cascades that regulate midbrain stem cell behavior as well as dopaminergic neurogenesis, differentiation and subtype specification.
The functions of Wnts, their receptors and their signaling pathways, with focus on new components of the Wnt/PCP signaling.
The function of nuclear receptors and their ligands in midbrain dopaminergic neuron development.
The identification of novel factors by single cell transcriptomic, proteomic and lipidomic approaches.
Control of midbrain dopaminergic neurogenesis by basic-helix-loop-helix transcription factors.
Stem cells and direct reprogramming for Parkinson’s disease (PD) cell replacement therapy and drug discovery
Improving protocols for the efficient differentiation of human stem cells (NES, ES, and iPS cells) into substantia nigra A9 dopaminergic neurons for cell replacement therapy and drug discovery.
Develop 2D and 3D in vitro models of midbrain tissue for PD drug discovery using human NES/ES/iPS cells with PD mutations and isogenic controls.
Examine the role of Wnt signaling in the pathogenesis of Parkinson’s disease.
Improve protocols for the direct in vitro reprogramming of somatic cells into substantia nigra A9 dopaminergic neurons.
Develop a novel cell replacement therapy for PD based on the direct in vivo reprogramming of striatal astrocytes in situ, into functional A9 dopaminergic neurons.
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International Journal of Molecular Sciencesno. 1 (2024): 683
Emilía Sif Ásgrímsdóttir, Luca Fusar Bassini,Pia Rivetti di Val Cervo,Daniel Gyllborg, Clàudia Puigsasllosas Pastor, Kawai Lee, Christopher L Grigsby, Saiful Islam,Peter Lönnerberg,Carlos Villaescusa,Carmen Saltó,Sten Linnarsson,
biorxiv(2024)
IBRO Neuroscience Reports (2023): S40-S40
Kaneyasu Nishimura,Shanzheng Yang,Ka Wai Lee,Emilía Sif Ásgrímsdóttir, Kasra Nikouei,Wojciech Paslawski, Sabine Gnodde,Guochang Lyu,Lijuan Hu,Carmen Saltó,Per Svenningsson,Jens Hjerling-Leffler,
biorxiv(2022)
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