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个人简介
Dr. Darrah is primarily interested in the mechanisms underlying the development and progression of autoimmunity in RA, with a particular focus on the peptidyl arginine deiminase (PAD) enzymes. These enzymes carry out the post-translational conversion of arginine to citrulline in a calcium-dependent reaction to generate the hallmark targets of the autoimmune response in RA, citrullinated proteins. PAD4 is a member of this enzyme family and is itself a target of autoantibodies in RA. Dr. Darrah is focused on understanding the development of these PAD4-activating autoantibodies over time and how they contribute to the development of erosive disease. Studies are underway to determine if the newly discovered antibody is mimicking a naturally-occurring PAD4 binding partner and to identify potentially pro-inflammatory effects of citrullinated proteins on effector cells of the immune system.
研究兴趣
论文共 64 篇作者统计合作学者相似作者
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Mekha A Thomas,Pooja Naik,Hong Wang,Jon T Giles, Alexander A Girgis,Seok-Young Kim, Tory P Johnson,Ashley M Curran, Jonathan D Crawford,Shaghayegh Jahanbani, Clifton O Bingham,William H Robinson,
Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2304199121-e2304199121
Cell Reports Medicineno. 5 (2024): 101569-101569
ACR OPEN RHEUMATOLOGYno. 2 (2024): 81-90
John B. Miller,Alison W. Rebman, Marcia Daniela Villegas de Flores,Hong Wang,Erika Darrah,John N. Aucott
THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE (2024): 20499361241242971-20499361241242971
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1890 (2023): 20220477
Timothy M Wilson,Joshua J Solomon, Stephen M Humphries,Jeffrey J Swigris,Faduma Ahmed,Hong Wang,Erika Darrah,M Kristen Demoruelle
The American journal of the medical sciencesno. 6 (2023): 480-487
Journal of Immunologyno. 4 (2023): 612-625
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