Erik J. Hembre - Lilly Research Laboratories

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Papers共 59 篇Author StatisticsCo-AuthorSimilar Experts

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Computational Design of Highly Signaling Active Membrane Receptors Through De Novo Solvent-Mediated Allosteric Networks

K.-Y. M. Chen,J. K. Lai, L. S. P. Rudden,J. Wang, A. M. Russell,K. Conners, M. E. Rutter,B. Condon, F. Tung, L. Kodandapani, B. Chau,X. Zhao,J. Benach, K. Baker,E. J. Hembre,P. Barth

Nature Chemistry（2025）

Cited0Views0WOSNATUREBibtex

Ensemble Docking Approach to Mitigate Pregnane X Receptor-Mediated CYP3A4 Induction Risk

Qi Chen,Xin Zhou,Jessica Rehmel, James P. Steele,Kjell A. Svensson,James P. Beck,Erik J. Hembre,Junliang Hao

JOURNAL OF CHEMICAL INFORMATION AND MODELING（2023）

Cited10Views0EIWOSBibtex

Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor

Xushan Wang,Erik J. Hembre,Paul J. Goldsmith,James P. Beck,Kjell A. Svensson,Francis S. Willard,Robert F. Bruns

Molecular pharmacologyno. 3 (2022): 176-187

Cited3Views0WOSBibtex

Novel Trifluoromethyl Pyrimidinone Compounds with Activity Against Mycobacterium Tuberculosis

Erik Hembre,Julie V. Early,Joshua Odingo,Catherine Shelton,Olena Anoshchenko,Junitta Guzman,Lindsay Flint,Devon Dennison,Matthew B. McNeil,Aaron Korkegian,Yulia Ovechkina,Paul Ornstein,Thierry Masquelin,Philip A. Hipskind,Tanya Parish

Frontiers in Chemistry（2021）

Cited1Views0WOSBibtex

Synthesis and Pharmacological Characterization of 2-(2,6-dichlorophenyl)-1-((1s,3r)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1h)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor

Journal of Medicinal Chemistry（2019）

Cited44Views0WOSBibtex

CCDC 1944257: Experimental Crystal Structure Determination

The Cambridge Structural Database (2019)

Cited0Views0Bibtex

Practical Asymmetric Fluorination Approach to the Scalable Synthesis of New Fluoroaminothiazine BACE Inhibitors

Pablo Garcia-Losada,Mario Barberis,Yuan Shi,Erik Hembre, Carolina Alhambra Jimenez,Leonard L. Winneroski,Brian M. Watson,Chauncey Jones,Amy C. DeBaillie,Francisco Martinez-Olid,Dustin J. Mergott

Organic process research & development（2018）

Cited11Views0Bibtex

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