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Eric Vivès has been working on the synthetic HIV-1 Tat protein for many years and originally performed in 1997 the full structure-activity relationship study which highlighted the cationic region of the protein to be responsible for the cellular translocation property. This Tat peptide has been then exploited worldwide for the cellular delivery of hundreds of different molecules (proteins, peptides, nucleic acids, liposomes, nanoparticles…). Later in 2003, he further investigated the mechanism of cell entry of this peptide and discovered that artifactual fixation conditions altered the pattern of the experimental data previously presented for this category of cell-penetrating peptides. Both works have been published in Journal of Biological Chemistry and have been numerously cited. He oriented recently his research in the design of original cancer cell-targeting peptides in order to deliver any devices loaded with drugs or pharmaceutical molecules specifically to the tumour cells. Along this line, inspired by the reference cell-targeting peptide developed by the Kessler’s group, namely the c(RGDfNMeV), he conceived a cyclisation procedure leading to the formation of a tetracyclopeptide c(RGDK) closed with an original urea bond between the alpha-amino group of the peptide and the epsilon amino group of the ring-closing amino acid. He is now involved in the design of peptide able to form stable nanoparticules with various kinds of nucleic acids (siRNAs, plasmids, mRNAs).
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论文共 81 篇作者统计合作学者相似作者
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Journal of agricultural and food chemistryno. 4 (2023): 1878-1884
iScienceno. 2 (2023): 106042-106042
JOURNAL OF PEPTIDE SCIENCE (2022)
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Stem Cells International (2022): 1-12
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Cell‐Penetrating Peptidespp.237-262, (2022)
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