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In order for bacterial pathogens to cause disease, they must obtain nutrients inside their vertebrate hosts. The primary nutrients that are limiting to the growth of bacteria inside vertebrates are metals. This is due to the fact that vertebrates have developed numerous metal chelation systems that serve as a host defense against microbial infection. This process is called nutritional immunity. My laboratory is interested in identifying the host and bacterial factors that are involved in this battle for metal during the pathogenesis of infectious diseases. We use techniques from biochemistry, molecular biology, cell biology, and chemistry to answer fundamental questions pertaining to the host-pathogen interaction. In particular, we focus on diseases caused by the important human pathogens Staphylococcus aureus (Staph infections), Bacillus anthracis (Anthrax), and Acinetobacter baumannii (leading cause of hospital infections and battlefield wound infections). The long term goal of our research is to develop novel therapies to treat microbial diseases.
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Papers共 328 篇Author StatisticsCo-AuthorSimilar Experts
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Proceedings of the National Academy of Sciences of the United States of Americano. 27 (2024): e2402422121-e2402422121
Antimicrobial agents and chemotherapyno. 4 (2024): e0150723-e0150723
Gustavo Rios-Delgado, Aubrey K G McReynolds, Emma A Pagella,Javiera Norambuena, Paul Briaud, Vincent Zheng, Matthew J Munneke, Jisun Kim, Hugo Racine,Ronan Carroll, Ehud Zelzion,Eric Skaar,
bioRxiv : the preprint server for biology (2024)
Molecular microbiology (2023)
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINEno. 11 (2023): 1234-1240
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Natureno. 7989 (2023): 1009-1016
Gina R Lewin, Ananya Kapur,Daniel M Cornforth,Rebecca P Duncan, Frances L Diggle,Dina A Moustafa,Simone A Harrison,Eric P Skaar,Walter J Chazin,Joanna B Goldberg,Jennifer M Bomberger,Marvin Whiteley
Proceedings of the National Academy of Sciences of the United States of Americano. 19 (2023): e2221542120-e2221542120
bioRxiv : the preprint server for biology (2023)
PLoS pathogensno. 5 (2023)
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