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Bio
My lab is interested in understanding the fundamental principles of how proteins are destroyed within cells. The cellular environment must constantly adapt to changing conditions and one mechanistic strategy commonly employed is the targeted modification of proteins by ubiquitin chains and subsequent degradation by the proteasome. The ubiquitin-proteasome system (UPS) can be viewed as the cellular waste management system. The UPS is utilized as the cellular quality control system as it is tasked with the degradation of potentially toxic misfolded and misassembled proteins. The inability of the UPS to properly destroy these proteins has been linked to various human pathologies including amyotrophic lateral sclerosis (ALS, commonly referred to as Lou Gehrig's disease), Parkinson's disease, and many human cancers. Thus, understanding the mechanisms of how the UPS recognizes proteins to be destroyed and how the pathway becomes dysfunctional will be instrumental in understanding the etiology of these diseases. The lab uses integrated approaches to understand UPS activity coupling biochemistry, cell biology, and systems-level approaches.
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Papers共 184 篇Author StatisticsCo-AuthorSimilar Experts
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Aaron M. D'Antona,Julie M. Lee,Melvin Zhang, Clarence Friedman,Tao He,Lidia Mosyak,Eric Bennett,Laura Lin, Maddison Silverman, Funi Cometa,Caryl Meade, Tyler Hageman,
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 3 (2024): 1931
SCIENTIFIC REPORTSno. 1 (2023): 1-13
The Plant cellno. 7 (2023): 2678-2693
Pierce W. Ford,Eric J. Bennett
Cell Reportsno. 11 (2023): 113278-113278
IISE Transactions on Healthcare Systems Engineeringpp.1-14, (2023)
Emily K Makowski,Hongwei Chen,Matthew Lambert,Eric M Bennett, Nicole S Eschmann,Yulei Zhang,Jennifer M Zupancic,Alec A Desai,Matthew D Smith,Wenjia Lou,Amendra Fernando, Timothy Tully,
Experimental Hematology (2022): S70-S70
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