His research has focused on brain computer interfaces and brain mapping – using engineering approaches to decode the brain to create novel diagnostics and treatments for disease ranging from brain tumors, stroke, chronic pain, and spinal cord injury. Dr. Leuthardt uses an integrated approach by employing multiple domains of expertise ranging from biomedical engineering, clinical neurosurgery, mathematical modeling, complex signal analysis, and computer programming. In addition to numerous peer-reviewed publications, Leuthardt has numerous patents on file with the U.S. Patent and Trademark Office for medical devices and brain computer interface technologies. Neuroprosthetics – devices linked to the brain that may lead to cures for paralysis, allow patients to move artificial limbs or restore other neurological functions.