基本信息
views: 6
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My interests lie in clinical and translational research in advanced prostate cancer, including trial design, and development of novel agents. I piloted the early trials targeting the androgen receptor in advanced prostate cancer, developing ketoconazole and contributing to an understanding of its mechanisms of activity and resistance. I subsequently was centrally involved with the development of two novel androgen signaling inhibitors, abiraterone acetate and apalutamide, from first in human studies to FDA approval.
I have also been involved in the early application of immunotherapy to prostate cancer, developing sipuleucel T from first in human studies through FDA approval, and undertaking the first in human testing of ipilimumab, the first immune check point inhibitor to be clinically developed.
Understanding the mechanisms of resistance in advanced prostate cancer has been a research focus. I was principal investigator of a $10 million multi-center Stand Up to Cancer (SU2C)/Prostate Cancer Foundation Dream Team Award undertaking deep genomic characterization of prostate cancer metastases, in order to elucidate patterns of resistance in abiraterone and/or enzalutamide treated patients. Important observations from this, and subsequent work have included unexpectedly high prevalence rates of treatment associated small cell/neuroendocrine prostate cancer (t-SCNC), as well key structural variants which contribute to progression of castration-resistant disease, observed in the largest Whole Genome Sequencing series to date of metastatic advanced prostate cancer specimens.
Research Interests
Papers共 679 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Shuang G Zhao, Matthew Bootsma,Stanley Zhou,Raunak Shrestha,Thaidy Moreno-Rodriguez,Arian Lundberg, Chu Pan,Christopher Arlidge, James R Hawley, Adam Foye,Alana S Weinstein,Martin Sjöström,
Nature genetics (2024)
CANCER IMMUNOLOGY RESEARCHno. 4 (2024): 453-461
Zenghua Fan,David Y. Oh,Anthony Wong,Katsuto Shinohara,Hao Nguyen, Caleb Hwang,Hewitt Chang,Alec Starzinski,Tony Li, Christopher De Leon, Marissa Gin,Eliezer Van Allen,
Cancer Researchno. 6_Supplement (2024): 4988-4988
Manuel Weber,Wolfgang P. Fendler,Aravind S. Ravi Kumar,Jeremie Calais,Johannes Czernin,Harun Ilhan,Fred Saad, Alexander Kretschmer, Turkay Hekimsoy,Sabine D. Brookman-May,Suneel D. Mundle,Eric J. Small,
European Urologyno. 6 (2024): 511-516
The Pharmacogenomics Journalno. 2 (2024): 1-8
David Alan Quigley,Julian C. Hong, Nicholas Lillis,Ali Sabbagh, Isabel D Friesner, Adina Bailey,Rahul Raj Aggarwal,Li Zhang,Meera Reddy Chappidi, Hari Singhal, Joel Greshock,Ke Zhang,
Journal of Clinical Oncologyno. 4_suppl (2024): 192-192
JU open plusno. 4 (2024)
Raunak Shrestha,Lisa N Chesner, Meng Zhang, Stanley Zhou, Adam Foye,Arian Lundberg,Alana S Weinstein,Martin Sjöström,Xiaolin Zhu,Thaidy Moreno-Rodriguez, Haolong Li, Su C/Pcf West Coast Prostate Cancer Dream Team,
Cancer research (2024)
JU open plusno. 4 (2024)
Aishwarya Subramanian, Meng Zhang,Marina Sharifi, Thaidy Moreno-Rodriguez, Eric Feng,Nicholas R Rydzewski, Raunak Shrestha, Xiaolin Zhu, Shuang G Zhao,Rahul Aggarwal,Eric J Small,Chien-Kuang Cornelia Ding,
bioRxiv : the preprint server for biology (2024)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn