My research focuses on translational neuro-oncology, with the overall goal being to develop new therapeutics for poor-prognosis brain tumors. I have developed normal neural stem cells for use as genetically accurate gain-of-function models for high-risk brain tumors, including models of high and low grade glioma as well as DIPG. We have also assembled an array of patient-derived pediatric brain tumor cell lines and xenograft models for therapeutic testing.