基本信息
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Bio
His laboratory uses novel approaches to single-molecule imaging for studying problems related to genome integrity. He enjoys fly fishing.
Research
Our group uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids. Our overall goal is to reveal the molecular mechanisms that cells use to repair, maintain, and decode their genetic information. This research combines aspects of biochemistry, physics, and nanoscale technology to answer questions about complex biological problems that cannot be easily addressed through traditional biochemical approaches. As part of our work, we have established robust experimental platforms that enable single molecule imaging of biochemical reaction mechanisms in a “high throughput” experimental format that can be applied to the study of protein-nucleic acid interactions. The advantages of our approaches are that we can see what proteins are bound to DNA, where they are bound, how they move, and how they interact with and influence other components of the system – all in real-time, at the level of a single reaction. We are applying this technology towards determining the physical basis for the mechanisms that proteins use to maintain genome integrity, with particular emphasis on reactions related to homologous DNA recombination. basis for the mechanisms that proteins use to maintain genome integrity, with particular emphasis on reactions related to homologous DNA recombination.
Research
Our group uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids. Our overall goal is to reveal the molecular mechanisms that cells use to repair, maintain, and decode their genetic information. This research combines aspects of biochemistry, physics, and nanoscale technology to answer questions about complex biological problems that cannot be easily addressed through traditional biochemical approaches. As part of our work, we have established robust experimental platforms that enable single molecule imaging of biochemical reaction mechanisms in a “high throughput” experimental format that can be applied to the study of protein-nucleic acid interactions. The advantages of our approaches are that we can see what proteins are bound to DNA, where they are bound, how they move, and how they interact with and influence other components of the system – all in real-time, at the level of a single reaction. We are applying this technology towards determining the physical basis for the mechanisms that proteins use to maintain genome integrity, with particular emphasis on reactions related to homologous DNA recombination. basis for the mechanisms that proteins use to maintain genome integrity, with particular emphasis on reactions related to homologous DNA recombination.
Research Interests
Papers共 176 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
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引用量
主题
期刊级别
合作者
合作机构
Genes & developmentno. 7-8 (2024): 354-354
SCIENCEno. 6672 (2023): eadj8543-eadj8543
Journal of Biological Chemistryno. 3 (2023): 104187-S642
Nature Communicationsno. 1 (2023): 1-16
NATURE BIOTECHNOLOGYno. 8 (2023): 1099-1106
Natureno. 7970 (2023): 640-+
Eric R Greene, Richard Muniz,Angelika Arada,D John Lee,Daphne Chen,Erin Thompson, Hiroki Yamamura,Justin M Kollman,James Fraser
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Author Statistics
#Papers: 169
#Citation: 10922
H-Index: 48
G-Index: 103
Sociability: 6
Diversity: 3
Activity: 151
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