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个人简介
The major goals of my research have been to understand how the prostate gland develops and how disruption of hormone receptor signaling pathways early in prostate development predisposes humans and rodents to neoplasia. Prostate neoplasia is a leading cause of urologic disease among men. Indeed, most lower urinary tract symptoms in men over age 50 are due to benign prostatic hyperplasia, and prostate cancer is the second leading cause of cancer-related deaths in men. Studies of genetically modified mice suggest that the androgen receptor (AR) plays a role in prostate neoplasia initiation. Androgens, like testosterone, and AR signaling are necessary for prostate development and homeostasis, and disruption of AR-mediated prostate development predisposes humans and rodents to prostate neoplasia by altering the gland’s phenotype early in life. Due to the involvement of AR in both prostate development and neoplasia, a thorough understanding of how AR controls cell proliferation and differentiation during prostate development will offer clues to key developmental events that reemerge in prostate neoplasia.
Research Interests
Cancer, Developmental Biology, Endocrinology, Epigenetics, Gene Regulation, Ion Channels
研究兴趣
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Eung Chang Kim,Jiaren Zhang, Andy Y Tang,Eric C Bolton,Justin S Rhodes, Catherine A Christian-Hinman,Hee Jung Chung
PLoS ONEno. 3 (2019): e0213800
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