Dr. Bouffet’s research focuses on paediatric brain tumours, and in particular in innovative clinical trials. This includes repurposing, such as the development of the vinblastine program for paediatric low grade glioma that has been going on since 2000. This also includes clinical trials of new drugs, in particular in the context of low grade glioma, high grade glioma, hypermutated tumours, ependymoma, medulloblastoma and diffuse pontine gliomas.

He also has an interest in brain repair and works closely with Dr. Mabbott on brain rehabilitation. Another aspect of his research relates to the development of paediatric neuro-oncology programs in low- and middle-income countries.