Eric P. Arnold

Pfizer Inc

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论文共 28 篇作者统计合作学者相似作者

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Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists

Brian S Gerstenberger,Ray Unwalla,Kathleen A Farley,Philippe Nuhant,Vincent M Lombardo,Wei Li,Kimberly Crouse,Richard K Frisbie,Eric P Arnold,Mark W Bundesmann,Gary M Chinigo,Andrew Flick,Neelu Kaila,Daniel Lamb,James J Mousseau, Nootaree Niljianskul,Mathieu Rappas,John I Trujillo,Michael L Vazquez,Atli Thorarensen,Mark E Schnute

Journal of medicinal chemistryno. 4 (2025): 4818-4828

引用0浏览0WOS引用

Design and Optimization of a Series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual Inhibitors of TYK2 and JAK1

Andrew Fensome,Catherine M. Ambler,Eric Arnold,Mary Ellen Banker,James D. Clark,Martin E. Dowty,Ivan Efremov,Andrew Flick,Brian S. Gerstenberger, Roger S. Gifford,Ariamala Gopalsamy,Martin Hegen,Jason Jussif,David C. Limburg,Tsung H. Lin,Betsy S. Pierce,Raman Sharma,John Trujillo,Felix F. Vajdos,Fabien Vincent,Zhao-Kui Wan,Li Xing,Xiaojing Yang,Xin Yang

Bioorganic & Medicinal Chemistry（2020）

引用12浏览0WOS引用

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases

Brian S. Gerstenberger,Catherine Ambler,Eric P. Arnold,Mary-Ellen Banker,Matthew F. Brown,James D. Clark,Alpay Dermenci,Martin E. Dowty,Andrew Fensome,Susan Fish,Matthew M. Hayward,Martin Hegen,Brett D. Hollingshead,John D. Knafels,David W. Lin,Tsung H. Lin,Dafydd R. Owen,Eddine Saiah,Raman Sharma,Felix F. Vajdos,Li Xing,Xiaojing Yang,Xin Yang,Stephen W. Wright

Journal of Medicinal Chemistry（2020）

引用52浏览0WOS引用

Parallel Synthesis Of Benzimidazoles Via Oxidative Cyclization

Daniel Schmitt,Eric Arnold, Prolay Mondal

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2019）

引用0浏览0引用

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Christopher J. Helal,Eric Arnold,Tracey Boyden,Cheng Chang,Thomas A. Chappie,Ethan Fisher,Mihaly Hajos,John F. Harms,William E. Hoffman,John M. Humphrey,Jayvardhan Pandit,Zhijun Kang,Robin J. Kleiman,Bethany L. Kormos,Che-Wah Lee, Jiemin Lun, Noha Maldad,Laura McDowell,Dina McGinnis,Rebecca E. O'Connor,Christopher J. O'Donnell,Adam Ogden,Mary Piotrowski,Christopher J. Schmidt,Patricia A. Seymour,Hirokazu Ueno, Nichole Vansell,Patrick R. Verhoest,Edward X. Yang

Journal of Medicinal Chemistry（2018）

引用26浏览0WOS引用

Discovery Of The Tyk2 Selective Inhibitor Pf-6826647 For The Treatment Of Crohn'S Disease, And Other Autoimmune Conditions

Brian Gerstenberger,Eric Arnold,Mary Ellen Banker,Matthew Brown,James Clark,Alpay Dermenci,Martin Dowty,Andrew Fensome,Matthew Hayward,Martin Hegen,Brett Hollingshead,John Knafels,David Lin,Tsung Lin,Dafydd Owen,Eddine Saiah,Raman Sharma,Felix Vajdos,Fabien Vincent,Stephen Wright,Li Xing,Xiaojing Yang,Xin Yang,Liying Zhang

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2018）

引用0浏览0引用

Application Of Structure-Based Design And Parallel Chemistry To Identify A Potent, Selective, And Brain Penetrant Phosphodiesterase 2a Inhibitor (Vol 60, Pg 5673, 2017)

Christopher J. Helal,Eric P. Arnold,Tracey L. Boyden,Cheng Chang,Thomas A. Chappie,Kimberly F. Fennell,Michael D. Forman,Mihaly Hajos,John F. Harms,William E. Hoffman,John M. Humphrey,Zhijun Kang,Robin J. Kleiman,Bethany L. Kormos,Erik A. Lachapelle,Che-Wah Lee,Jiemin Lu,Noha Maklad,Laura Mcdowell,Scot Mente,Rebecca E. O'Connor,Jayvardhan Pandit,Mary Piotrowski,Anne W. Schmidt,Christopher J. Schmidt,Hirokazu Ueno,Patrick R. Verhoest,Edward X. Yang

JOURNAL OF MEDICINAL CHEMISTRY（2018）

引用0浏览0引用

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez,Neelu Kaila,Joseph W. Strohbach,John D. Trzupek,Matthew F. Brown,Mark E. Flanagan,Mark J. Mitton-Fry,Timothy A. Johnson,Ruth E. TenBrink,Eric P. Arnold,Arindrajit Basak,Steven E. Heasley,Soojin Kwon,Jonathan Langille,Mihir D. Parikh, Sarah H. Griffin,Jeffrey M. Casavant,Brian A. Duclos,Ashley E. Fenwick,Thomas M. Harris,Seungil Han,Nicole Caspers,Martin E. Dowty,Xin Yang,Mary Ellen Banker,Martin Hegen,Peter T. Symanowicz, Li,Lu Wang,Tsung H. Lin,Jason Jussif,James D. Clark,Jean-Baptiste Telliez,Ralph P. Robinson,Ray Unwalla

Journal of Medicinal Chemistry（2018）

引用132浏览0WOS引用

132

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-difluorocyclopropyl)((1r,5s)-3-(2-((1-methyl-1h-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome,Catherine M. Ambler,Eric Arnold,Mary Ellen Banker,Matthew F. Brown,Jill Chrencik,James D. Clark,Martin E. Dowty,Ivan V. Efremov,Andrew Flick,Brian S. Gerstenberger,Ariamala Gopalsamy,Matthew M. Hayward,Martin Hegen,Brett D. Hollingshead,Jason Jussif,John D. Knafels,David C. Limburg,David Lin,Tsung H. Lin,Betsy S. Pierce,Eddine Saiah,Raman Sharma,Peter T. Symanowicz,Jean-Baptiste Telliez,John I. Trujillo,Felix F. Vajdos,Fabien Vincent,Zhao-Kui Wan,Li Xing,Xiaojing Yang,Xin Yang,Liying Zhang

Journal of Medicinal Chemistry（2018）

引用135浏览0WOS引用

135

Steric Redirection of Alkylation in 1 H -Pyrazole-3-carboxylate Esters

Stephen W. Wright,Eric P. Arnold,Xiaojing Yang

Tetrahedron Letters（2017）

引用9浏览0引用

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