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个人简介
After obtaining my PhD in Molecular Biology from Russian Academy of Science, I had a postdoctoral training at Albert Einstein College of Medicine in New York under the supervision of Dr. David I. Goldman, a leading investigator in the area of methotrexate (MTX) resistance in leukemia. Following my interest in Nitric Oxide (NO) biology, I moved to UT-Health Science Center in Houston, to join the laboratory of Dr. Ferid Murad, a pioneer and leader in the NO field. Starting as Research Scientist, I progressed to the position of Assistant Professor at the Department of Internal Medicine/Cardiology of UT-HSC in Houston. Since 1999, my studies were primarily focused on the mechanisms that regulate sGC activity and function. I investigated the role of transcription in sGC regulation, structure-functional relationship and mechanisms of pharmacologic regulation of the sGC enzyme, identified new splice variant of sGC and established their role in oxidative stress and the development of sGC-related pathologies. Following the observation that some of the splice variants of sGC exhibit age-dependent expression, I became interested in the effect of ageing on sGC function. My current research efforts are directed towards the discovery of new physiological functions of heterodimeric Soluble Guanylyl Cyclase (sGC) enzyme. sGC, the unique receptor for Nitric Oxide (NO), catalyzes the synthesis of secondary messenger molecule cGMP. NO/cGMP pathway plays critical role in the cardiovascular function, including activation of the relaxation of vascular smooth muscle and inhibition of platelet aggregation. In the recent studies, our laboratory demonstrated decreased sGC activity in the brain tissue of older animals. Lack of this important enzyme causes increased stiffness of blood vessels, decreases cerebral blood flow and prevents proper oxygenation of brain tissue. In our ongoing study, we are planning to investigate how the loss of sGC enzymatic activity affects cerebral blood flow (CBF) and brain function during aging. Significant decrease in CBF is a major hemodynamic alteration leading to the degeneration of neuronal tissue and age-related cognitive decline, including dementia. Currently, there is no effective treatments for dementia. Recent US demographic trend indicates that age-related dementia is becoming a serious public health crisis. Understanding the molecular processes that govern this disease is critical for the design of effective treatment measures. This represents an ultimate goal of research studies in my laboratory.
研究兴趣
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Radwa Awad, Christopher Beeghly, Tatiana Barichello,Vijayasree V. Giridharan,Emil Martin,Iraida Sharina
Physiologyno. S1 (2024)
Iraida Sharina, Emil Martin
Science (New York, N.Y.)no. 6670 (2023): 519-519
The Journal of pharmacology and experimental therapeuticsno. 2 (2022): 164-175
Kevin M Gayler,Jeremy M Quintana,Jordan Mattke,Michael A Plunk,Jessica H Kostyo, Johann W Karunananthan, Harold Nguyen,Mina Shuda,Liam D Ferreira, Hannah Baker,Alexandra L Stinchcomb,Iraida Sharina,
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