基本信息
浏览量:0
职业迁徙
个人简介
Description of Research Expertise
Research Interests
We study the molecular biology of human papillomaviruses, focusing on how these viruses cause cancer and evade immune detection.
Keywords
Human papillomavirus, tumor virus, cancer virology, transformation, innate immunity, HPV
Research Details
Human papillomavirus (HPV) infection causes 5% of cancer cases worldwide, and HPV infection is the cause of all cervical cancer, some oropharyngeal cancer, and other cancers. Papillomaviruses are extraordinarily diverse, and fewer than fifteen of the >200 known HPVs are oncogenic. My research is focused on understanding the mechanisms by which HPVs manipulate the host cellular environment to evade immune responses and sometimes cause cancer.
HPV-mediated transformation: Our previous proteomic and transcriptional analyses identified many HPV targets in human cells. One of these, PTPN14, is a non-receptor tyrosine phosphatase that is specifically targeted for degradation by the oncogenic HPVs. We are working to understand the nature of PTPN14 and other targets in HPV-infected and uninfected cells and to determine the mechanistic basis by which PTPN14 degradation might contribute to carcinogenesis.
HPV modulation of innate immune responses: Although only a handful of the HPVs are oncogenic, all of them encode proteins that alter the regulation of host immune signaling. Our systematic studies also identified many new HPV targets that appear to be involved in changing immune responses in infected cells. We plan to validate these targets and extend these studies to include systematic analyses of the mechanisms by which oncogenic and non-oncogenic HPVs evade immune detection.
We are a collaborative, enthusiastic research group interested in using molecular biology, cell biology, and systems approaches to understanding HPV-host interactions and cancer.
Rotation Projects
Projects are available in each of these broad areas. Please contact Dr. White for details.
Research Interests
We study the molecular biology of human papillomaviruses, focusing on how these viruses cause cancer and evade immune detection.
Keywords
Human papillomavirus, tumor virus, cancer virology, transformation, innate immunity, HPV
Research Details
Human papillomavirus (HPV) infection causes 5% of cancer cases worldwide, and HPV infection is the cause of all cervical cancer, some oropharyngeal cancer, and other cancers. Papillomaviruses are extraordinarily diverse, and fewer than fifteen of the >200 known HPVs are oncogenic. My research is focused on understanding the mechanisms by which HPVs manipulate the host cellular environment to evade immune responses and sometimes cause cancer.
HPV-mediated transformation: Our previous proteomic and transcriptional analyses identified many HPV targets in human cells. One of these, PTPN14, is a non-receptor tyrosine phosphatase that is specifically targeted for degradation by the oncogenic HPVs. We are working to understand the nature of PTPN14 and other targets in HPV-infected and uninfected cells and to determine the mechanistic basis by which PTPN14 degradation might contribute to carcinogenesis.
HPV modulation of innate immune responses: Although only a handful of the HPVs are oncogenic, all of them encode proteins that alter the regulation of host immune signaling. Our systematic studies also identified many new HPV targets that appear to be involved in changing immune responses in infected cells. We plan to validate these targets and extend these studies to include systematic analyses of the mechanisms by which oncogenic and non-oncogenic HPVs evade immune detection.
We are a collaborative, enthusiastic research group interested in using molecular biology, cell biology, and systems approaches to understanding HPV-host interactions and cancer.
Rotation Projects
Projects are available in each of these broad areas. Please contact Dr. White for details.
研究兴趣
论文共 54 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF VIROLOGYno. 3 (2024)
Angela L Rasmussen, Gigi K Gronvall,Anice C Lowen,Felicia Goodrum,James Alwine,Kristian G Andersen,Simon J Anthony,Joel Baines, Arinjay Banerjee,Andrew J Broadbent, Christopher B Brooke,Samuel K Campos,
Journal of virologyno. 3 (2024): e0007424-e0007424
bioRxiv : the preprint server for biology (2024)
CANCER DISCOVERYno. 4 (2023): 814-816
James C Romero-Masters,Miranda Grace,Denis Lee, Joshua Lei, Melanie DePamphilis,Darya Buehler,Rong Hu,Ella Ward-Shaw,Simon Blaine-Sauer,Nathalie Lavoie,Elizabeth A White,Karl Munger,
Joangela Nouel,Elizabeth A White
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn