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Research interests
Aberrant secretion of neurotransmitters, hormones or immune mediators contributes to the pathology of a wide variety of chronic neurological, endocrine and inflammatory diseases ranging from stress and hypertension through to asthma and irritable bowel syndrome.
Research in our lab is focussed on identifying the signalling pathways and molecules controlling secretion from neurones and mast cells, with a special interest in voltage-gated (CaV), ligand-gated (P2X and nAChR), receptor-operated (TRPC) and store-operated (Orai) calcium channels, IgE and G protein coupled receptors (P2Y, Histamine), and SNARE regulatory proteins (synaptotagmins, Doc2 and Munc13).
Most of our work is performed at the level of isolated primary cells using high resolution techniques including patch-clamp electrophysiology, carbon fibre amperometry, calcium imaging and total internal reflection fluorescence microscopy with various fluorescence-based biosensors.
Recent highlights of our research include (1) the discovery of ATP-sensitive P2X receptors on human lung mast cells, activation of which may contribute to the pathophysiology of asthma, (2) the first demonstration of Munc13 as an essential effector of phospholipase C-coupled G protein coupled receptor regulation of neurotransmitter release in mammalian cells, and (3) the modulatory action of synaptotagmin IV on the calcium-sensitivity of the neuronal fusion machinery.
研究兴趣
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Grace Wilde, Shannon Keating, Emma Marczak, Schuyler McMahon, Laura Naurath,Elizabeth Seward, Abigail Youssef, Sarah Stair, Sheila Gilligan
PEDIATRIC RESEARCHno. 4 (2022): 1197-1198
Andrew Juan, Amery Slover, Marie-Claire Smith, Kathryn Ohm, Olivia McSoley,Elizabeth Seward, Grace Rizzuto,Sheila Gilligan
Physiological Reportsno. 5 (2017)
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