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I am a structural biologist interested in how proteins are regulated by conformational changes, and have made significant contributions over the years to the analysis of protein kinases. Protein kinases represent a diverse set of molecular machines, carrying out precise programs of binding events, conformational changes and chemistry, often in a cascade. Our work has primarily focused on MAP kinase modules, and recently we have begun to study another short cascade comprised of the kinases WNK and OSR1/SPAK. These enzymes are medically important. Further, WNK1 itself is a salt sensor, a process that there is almost no data on. We are currently studying how WNK is regulated by salt or chloride, and how salt effects are transmitted into the next conformational step, which is breaking interactions with an autoinhibitory domain in WNK1. Our goal is a complete picture of the mechanism of the cascade. A secondary goal of my work is to learn enough about the mechanism of action of protein kinases to identify novel approaches toward drug discovery.
Research Interests
Papers共 191 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv : the preprint server for biology (2023)
Cancer Researchno. 12_Supplement (2022): LB031-LB031
Cancer Researchno. 12_Supplement (2022): LB506-LB506
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Author Statistics
#Papers: 192
#Citation: 17849
H-Index: 59
G-Index: 123
Sociability: 6
Diversity: 3
Activity: 29
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