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个人简介
1975 - graduated from the Faculty of Chemistry, Moscow State Lomonosov University.
1975 - 1982 - worked at the Chemistry Department of Moscow State University, and in 1980 defended PHD thesis: "Microspheric forms of immobilized chymotrypsin for photography" In 1989-1990, had a 9-month internship at the Department of Biochemistry, University of Turku (Finland).
1982 - Senior researcher at the Department of Biochemistry, PFUR.
1996 - Associate Professor.
2002 - defended the doctoral thesis "Investigation of the physico-chemical and biological properties of native, immobilized and conjugated L-lysine-a- oxidase from Trichoderma harzianum Rifai».
2003 - Professor at the Department of Biochemistry.
Awards:
1989 - the work "The search of L-lysine-alpha-oxidase producers, isolation and purification of the enzyme" was awarded the prize of the USSR Ministry of Health.
2012 - Veteran PFUR (honorary title, assigned to the staff members, who worked more than 30 years in PRUR)
Scientific work is devoted to the study of antitumor enzyme L-lysine oxidase. The enzyme is highly specific in relation to the essential amino acids and catalyzes the reaction of oxidative deamination of L-lysine, which leads to the reduction of its concentration and accumulation of hydrogen peroxide, which is able to inhibit the synthesis of DNA, RNA and proteins. Presently the methods of L-lysine oxidase application for tumor therapy are elaborated.
研究兴趣
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FEBS OPEN BIO (2021): 199-199
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