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Bio
Elena Bichenkova is a Reader in Medicinal Chemistry. Having graduated in Chemistry (BSc - 1983) with a PhD in NMR structural studies of nucleic acids (1993, Russia), Elena continued her research in the USA at Purdue University (1992, 1994) and then at the University of Texas (1996) collaborating with the first-rank NMR laboratory of Prof. David G. Gorenstein. After being awarded a Royal Society/NATO Postdoctoral Fellowship in 1996, she joined the University of Manchester as a Research Fellow. In January 2004 Elena was appointed by the School of Pharmacy & Pharmaceutical Sciences as a Lecturer in Medicinal Chemistry followed by promotion to the Senior Lecturer (2009) and then to Reader (2013). Her research focus is to contribute to the development of a new generation of clinically and commercially useful diagnostic tools, therapeutics and reagents for diagnosis and treatment of diseases through the integrating medicinal, synthetic, computational and analytical chemistry with structural biology (i.e. NMR and molecular modelling).
Elena’s research is multidisciplinary and primarily concerns nucleic acids chemistry, biochemistry and the study of structural aspects of nucleic acids by high-resolution NMR spectroscopy. These are synergised with high-level computational approaches and other biophysical methods, including steady state and time-resolved fluorescence spectroscopy.
Working in the DDA group Elena applied her expertise in biophysics and conformational analysis to various areas of medicinal chemistry, biochemistry and molecular biology. These included study of the structural aspects of processes occurring within nucleic and investigation of molecular mechanisms of ligand-nucleic acid interactions, which were vital elements in structure-based rational drug design. The success in this area has led on to the discovery of the first examples of synthetic inhibitors of a ribozyme (ribonuclease P, and the first paper related to this discovery has been published in Biochemistry).
For the last few years Elena has focused her research predominantly on the development of novel approaches for genomic and post-genomic molecular diagnostics, which will provide new generic tools applicable to any nucleic acid detection.
The most recent research of Elena's group is focused on the structural aspects of a new type of artificial ribonucleases with high catalytic turnover and hydrolytic efficiency using high-field 2D NMR spectroscopy and restrained Molecular Dynamics. EPSRC (2006-2009) have supported the investigations of the fundamental processes at the molecular level of these unusual catalytic systems to identify structural rules and molecular mechanisms governing their biochemical activity.
Research Interests
Papers共 122 篇Author StatisticsCo-AuthorSimilar Experts
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Daria Chiglintseva,David J. Clarke,Aleksandra Sen’kova, Thomas Heyman,Svetlana Miroshnichenko, Fangzhou Shan,Valentin Vlassov,Marina Zenkova,Olga Patutina,Elena Bichenkova
Biomaterials (2024): 122604-122604
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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TISSUE ENGINEERING PART Ano. 11-12 (2023): 392-393
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Mengisteab Gebrezgiabher,Waleed A Zalloum,David J Clarke,Steven M Miles,Antonina A Fedorova,Marina A Zenkova,Elena V Bichenkova
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