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个人简介
Short bio
Elena Hidalgo graduated in Pharmacy at the Universitat de Barcelona, where she obtained her PhD at the Biochemistry Department in 1991. She performed two postdoctoral stages the labs of Bruce Demple (Harvard School of Public Health, Boston) and Nic Jones (Imperial Cancer Research Fund, London). She was recruited by Universitat Pompeu Fabra (Barcelona) in 2000, where she is now full professor. As a University member, she is both teaching and working on research as the co-director of the Oxidative Stress and Cell Cycle Group. José Ayté, the other co-leader of the group, works on cell cycle. Our students share knowledge and information, as should be expected for a good scientific practice in science. In the vast majority of the group’s publications, only Dr. Ayté or Dr. Hidalgo sign as corresponding author, not both. It is therefore trivial to identify the relevant leadership in each publication (please check the complete list at https://www.upf.edu/web/osccg/relevant-articles).
Indicators of Quality in Scientific Production
Published articles: 92
Published articles in Q1: 72; Published articles in D1: 34
h-index: 36
Thesis supervised (2012-2022): 8 (Natalia Gabrielli, Isabel Calvo, Sarela García-Santamarina, Esther Paulo, Alba Domènech, Luis Marte, Clàudia Salat-Canela, Rodrigo Fraile). On-going supervised Thesis: 3
5 evaluated research periods (last: 2012-2017)
6 evaluated teaching periods (last: 2013-2017)
ICREA Academia (2010-2014) (2015-2019) (2021-2026)
Research interests and scientific contributions
Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, reactive oxygen species such as hydrogen peroxide also exert signaling roles: they may activate antioxidant cascades, and endogenous increases of these species may even improve the overall fitness of the cell and trigger life span. Our lab uses the eukaryotic model system Schizosaccharomyces pombe to study the toxicity associated to oxygen-derived species, specifically protein oxidation and aggregation, and to describe the signaling processes controlled by oxidants.
The beauty of working with a unicellular eukaryote is that the molecular basis of biological processes can be studied to the very deep detail, and that unexpected cross-talks between cellular processes (oxidative stress and autophagy, splicing and meiosis, traffic and inhibition of cell polarity…) can be investigated within a sensible time frame. We collaborate with many fission yeast researchers (in fact, we organized the last international biannual Pombe meeting in Barcelona in 2019). Currently, we have two manuscripts under evaluations from our international collaborators (Ying Huang in China and Martin Prevorovsky in Czeck Republic). Lastly, we try to contribute to general science with ideas and resources, such as the generation of a genetically encoded reporter to measure in vivo oxidative stress.
We have managed to receive Spanish funding since we started to work in Spain, we have more than 80 publications to spread the generated knowledge. We have also received funding to support part of our proteomic-based research from Horizon 2020.
研究兴趣
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PLOS GENETICSno. 6 (2024): e1011316-e1011316
CRC Press eBookspp.49-53, (2023)
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Free Radical Biology and Medicine (2023): 3-3
Antioxidants (Basel, Switzerland)no. 10 (2023): 1810-1810
Antioxidants (Basel, Switzerland)no. 3 (2023)
Antioxidantsno. 3 (2023): 706-706
Javier Encinar Del Dedo, Rafael López-San Segundo,Alicia Vázquez-Bolado, Jingjing Sun,Natalia García-Blanco,M Belén Suárez, Patricia García, Pauline Tricquet,Jun-Song Chen, Peter C Dedon,Kathleen L Gould,Elena Hidalgo,
Research square (2023)
Susanna Boronat, Margarita Cabrera,Montserrat Vega, Jorge Alcalá, Silvia Salas-Pino,Rafael R Daga, José Ayté,Elena Hidalgo
International journal of molecular sciencesno. 13 (2023): 11202-11202
Montserrat Vega,Ruben Barrios,Rodrigo Fraile, Kevin de Castro Cogle,David Castillo,Roger Anglada,Ferran Casals,Jose Ayte, Ernesto Lowy-Gallego,Elena Hidalgo
NUCLEIC ACIDS RESEARCHno. 22 (2023): 12161-12173
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