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My lab investigates how the social brain circuit develops and what happens to it when something goes wrong. We use zebrafish as our animal model because they are social and completely transparent. We can monitor activity throughout the entire brain, with single cell resolution, from fertilization to the onset of social behaviour.
We have designed new behavioural assays to study social preference in young fish while presenting both real and virtual stimuli. We use a mix of anatomical (mapping of immediate early gene activation) and functional methods (two-photon calcium imaging) to monitor activity throughout the developing brain while we present social stimuli and monitor behavioural responses. Our projects are focused on identifying the neural circuit underlying social preference and characterizing the influence of genetic and environmental perturbations during early life.
We have designed new behavioural assays to study social preference in young fish while presenting both real and virtual stimuli. We use a mix of anatomical (mapping of immediate early gene activation) and functional methods (two-photon calcium imaging) to monitor activity throughout the developing brain while we present social stimuli and monitor behavioural responses. Our projects are focused on identifying the neural circuit underlying social preference and characterizing the influence of genetic and environmental perturbations during early life.
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Gareth T Powell, Ana Faro,Yuguang Zhao,Heather Stickney,Laura Novellasdemunt,Pedro Henriques,Gaia Gestri, Esther Redhouse White,Jingshan Ren,Weixian Lu,Rodrigo M Young,Thomas A Hawkins,
Science (New York, N.Y.)no. 6695 (2024): 573-579
Molecular autismno. 1 (2023): 23-23
biorxiv(2022)
crossref(2020)
Behavioral and Neural Genetics of Zebrafishpp.451-480, (2020)
crossref(2020)
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