基本信息
views: 14
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
I am an experienced cancer biologist, a Laboratory Head at St Vincent's Institute of Medical Research and a Victorian Cancer Agency Mid-Career Research Fellow (2020-2024).
I use my expertise in chromatin biology and DNA damage response to understand the mechanisms behind genome instability in cancer and identify novel therapeutic approaches in relapsed ovarian cancer. My studies focus on understanding the mechanisms of DNA repair and DNA damage response at the RNA Polymerase I (Pol I) genes (the ribosomal RNA (rRNA) genes), the largest clustered gene arrangement in the human genome, and deciphering the strong interplay between rRNA genes instability and genome-wide instability. I also investigate the mechanisms underlying rewiring of the DNA damage response in chemo-resistant ovarian cancer to identify novel therapeutic targets in chemotherapy-resistant ovarian cancer. I lead a group within an inspiring and interactive collaborative program of scientists and clinicians at the Peter MacCallum Cancer Centre, with track records of successful collaborative research that established targeting Pol I transcription as a new treatment paradigm in cancer therapy.
In 2018, I received the prestigious Highly Commended Peter Mac Lea Medal, which recognises outstanding emerging female research leaders and was the inaugural participant in a cancer research exchange program between the Peter Mac and the Dana-Farber Cancer Institute in Boston to establish collaborations in novel DNA repair therapies to advance our expertise in the DNA repair field.
Research Interests
Papers共 89 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
SCIENCE ADVANCESno. 10 (2024)
Kylee H. Maclachlan, Kezia Gitareja,Jian Kang,Andrew Cuddihy, Yuxi Cao,Nadine Hein,Carleen Cullinane, Ching-Seng Ang,Natalie Brajanovski,Richard B. Pearson,Amit Khot,Elaine Sanij,
Molecular Therapy: Oncologyno. 1 (2024): 200771-200771
Science Advancesno. 10 (2024): eadj8803-eadj8803
Sean Harrop,Phillip C. Nguyen,David Byrne, Clarissa Wilson,Georgina L. Ryland,Tamia Nguyen,Mary Ann Anderson,Seong Lin Khaw, Michelle Martin,Ing Soo Tiong,Elaine Sanij,Piers Blombery
EJHAEMno. 4 (2023): 1105-1109
Elaine Sanij,Jiachen Xuan,Natalie Brajanovski, Diannita Kwang,Keefe Chan, Henry Beetham,Kaylene Simpson,Linda Mileshkin,Clare Scott,Richard B. Pearson
CANCER SCIENCE (2023): 189-189
Cited0Views0Bibtex
0
0
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2022)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn