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In the field of regenerative medicine, significant progress has been made in cell-based therapies, while the manipulation of the stem cell niche to promote tissue regeneration has received less attention. A major component of the niche is peripheral nerves, which also provide a range of essential signals to the organs of the body, controlling functions such as heart rate and digestion. There is evidence that peripheral nerves are essential for the development, function and replacement of cells in numerous tissues and furthermore that neuronal signals are themselves vital within all three of these areas.
The mechanistic role of stem/progenitor cells particularly interests me, particularly the reactivation and manipulation of resident progenitor cells to maintain tissue homeostasis and promote repair. Using the acini-ductal network of the developing and adult human and murine salivary gland as models of epithelial organogenesis and homeostasis, I have previously demonstrated that parasympathetic nerves preferentially establish, maintain and replenish functional saliva-producing acinar cells via progenitor cells marked by the transcription factor SOX2. My group is working to regenerate salivary gland epithelial tissue, injured by radiation therapy, by combining an exogenous progenitor cell transplant system with an endogenous reactivation method. This will allow a more targeted approach to reinnervating injured organs and as such improving organ function and regeneration.
In the field of regenerative medicine, significant progress has been made in cell-based therapies, while the manipulation of the stem cell niche to promote tissue regeneration has received less attention. A major component of the niche is peripheral nerves, which also provide a range of essential signals to the organs of the body, controlling functions such as heart rate and digestion. There is evidence that peripheral nerves are essential for the development, function and replacement of cells in numerous tissues and furthermore that neuronal signals are themselves vital within all three of these areas.
The mechanistic role of stem/progenitor cells particularly interests me, particularly the reactivation and manipulation of resident progenitor cells to maintain tissue homeostasis and promote repair. Using the acini-ductal network of the developing and adult human and murine salivary gland as models of epithelial organogenesis and homeostasis, I have previously demonstrated that parasympathetic nerves preferentially establish, maintain and replenish functional saliva-producing acinar cells via progenitor cells marked by the transcription factor SOX2. My group is working to regenerate salivary gland epithelial tissue, injured by radiation therapy, by combining an exogenous progenitor cell transplant system with an endogenous reactivation method. This will allow a more targeted approach to reinnervating injured organs and as such improving organ function and regeneration.
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论文共 41 篇作者统计合作学者相似作者
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Materialiapp.102115, (2024)
Frontiers in Biomaterials Science (2024)
Anna Appios,James Davies,Sofia Sirvent,Stephen Henderson,Sébastien Trzebanski,Johannes Schroth, Morven L. Law, Inês Boal Carvalho, Howard Yuan-Hao Kan, Shreya Lovlekar,Christina Major,Andres Vallejo,
biorxiv(2024)
Developmental cellno. 22 (2022): 2550-2565.e5
SSRN Electronic Journal (2022)
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