In the last decade the focus of his research has been on translational oncology and molecular imaging. These research activities resulted in over 300 publications in peer reviewed journals and chapters in books.

He is also active in several national and international societies such as IASLC, EORTC, ASCO and AACR. He served as a chair of multidisciplinairy task force for development of clinical guidelines in small cell lung cancer in The Netherlands.

He is on the review board of several major oncology journals and co-organised several national meetings on thoracic oncology and (post) graduate teaching courses. Egbert Smit has been involved as a promotor and co-reader of over 20 PhD students in The Netherlands.