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His work in developmental biology has contributed to the realization that antero-posterior and dorso-ventral patterning genes have been conserved throughout animal evolution. His work on Chordin, a secreted antagonist of ventral BMP signals that is regulated by proteolytic cleavage, has provided a new paradigm for intracellular signaling.
He is a member of the Pontifical Academy of Sciences in The Vatican, a corresponding Member of the Latin American Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, and a Member of the National Academy of Sciences. He serves on the Scientific Board of the Pew Trusts Latin American Program.
The De Robertis laboratory studies how long-range cell communication between the dorsal and ventral sides of the embryo occurs through the diffusion of growth factor antagonists. Investigations on the Chordin BMP antagonist showed that facilitated diffusion of a morphogen takes place in the narrow extracellular space that separates the ectoderm from the endomesoderm. This gradient is further integrated with Wnt signaling through the sequestration of the enzyme GSK3 inside multivesicular endosomes.
He is a member of the Pontifical Academy of Sciences in The Vatican, a corresponding Member of the Latin American Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, and a Member of the National Academy of Sciences. He serves on the Scientific Board of the Pew Trusts Latin American Program.
The De Robertis laboratory studies how long-range cell communication between the dorsal and ventral sides of the embryo occurs through the diffusion of growth factor antagonists. Investigations on the Chordin BMP antagonist showed that facilitated diffusion of a morphogen takes place in the narrow extracellular space that separates the ectoderm from the endomesoderm. This gradient is further integrated with Wnt signaling through the sequestration of the enzyme GSK3 inside multivesicular endosomes.
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论文共 229 篇作者统计合作学者相似作者
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Ulrik Ringborg,Joachim von Braun,Julio Celis,Michael Baumann,Anton Berns,Alexander Eggermont, Edith Heard, Manuel Heitor,Mammen Chandy,Chien-Jen Chen,Alberto Costa,Francesco De Lorenzo,
Molecular oncologyno. 2 (2024): 245-279
Nydia Tejeda-Muñoz,Yagmur Azbazdar,Eric A Sosa, Julia Monka, Pu-Sheng Wei, Grace Binder,Kuo-Ching Mei, Yerbol Z Kurmangaliyev,Edward M De Robertis
Biology open (2024)
BIOESSAYSno. 1 (2024): e2300179-e2300179
Cells & Developmentpp.203921-203921, (2024)
Molecular & cellular oncologyno. 1 (2023): 2218147-2218147
Cells & developmentpp.203897-203897, (2023)
Yagmur Azbazdar,Nydia Tejeda-Munoz, Julia C. Monka,Alex Dayrit, Grace Binder,Gunes Ozhan,Edward M. De Robertis
iScienceno. 10 (2023): 108075-108075
Nydia Tejeda-Munoz,Yagmur Azbazdar, Julia Monka, Grace Binder,Alex Dayrit,Raul Ayala,Neil O'Brien,Edward M De Robertis
bioRxiv : the preprint server for biology (2023)
Nydia Tejeda-Muñoz,Yagmur Azbazdar, Julia Monka, Grace Binder, Alex Dayrit,Raul Ayala, Neil O’Brien,Edward M. De Robertis
crossref(2023)
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