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个人简介
Research Interests:
Drug and Xenobiotic-induced Toxicity
3D Microphysiological Systems aka Tissue Chips
In the broadest sense, the Kelly lab research interests are within the realm of preclinical biology. In particular, we are interested in applying novel technology platforms to address the 3 Rs of toxicology in animal testing, reduce, refine and replace.
Active areas of research in the Kelly lab focus on ex vivo modeling of human organ physiology and toxicological responses to drug/xenobiotic challenge. These project makes use of “organs on chips” or microphysiological systems (MPS) populated with primary and stem-cell derived cell types to recapitulate two key ADME organs, the liver and kidney as alternatives to preclinical animal toxicology studies.
Recent work is extending MPS technologies to model select human diseases as well as how organs respond to the extreme environment of microgravity on the International Space Station.
Drug and Xenobiotic-induced Toxicity
3D Microphysiological Systems aka Tissue Chips
In the broadest sense, the Kelly lab research interests are within the realm of preclinical biology. In particular, we are interested in applying novel technology platforms to address the 3 Rs of toxicology in animal testing, reduce, refine and replace.
Active areas of research in the Kelly lab focus on ex vivo modeling of human organ physiology and toxicological responses to drug/xenobiotic challenge. These project makes use of “organs on chips” or microphysiological systems (MPS) populated with primary and stem-cell derived cell types to recapitulate two key ADME organs, the liver and kidney as alternatives to preclinical animal toxicology studies.
Recent work is extending MPS technologies to model select human diseases as well as how organs respond to the extreme environment of microgravity on the International Space Station.
研究兴趣
论文共 184 篇作者统计合作学者相似作者
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Kendan A Jones-Isaac,Kevin A Lidberg,Catherine K Yeung,Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig,Paul Koenig,Stefanie Countryman,Jonathan Himmelfarb,Edward J Kelly
NPJ microgravityno. 1 (2024): 54-54
PHARMACEUTICSno. 2 (2024): 285
Christopher Arian, Eimear O Mahony,James W MacDonald,Theo K Bammler, Mark Donowitz,Edward J Kelly,Kenneth E Thummel
Drug metabolism and disposition: the biological fate of chemicalspp.DMD-AR, (2024)
Reference Module in Biomedical Sciences (2024)
Kevin A Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang,James W MacDonald,Theo K Bammler, Justina Calamia,Kenneth E Thummel, Catherine K Yeung, Stefanie Countryman,Paul Koenig,
NPJ microgravityno. 1 (2024): 75-75
ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) (2024)
Andrew Hart,Francine Cesar,Leila R Zelnick, Nick O'Connor, Zoie Bailey, Jordan Lo,Kirk Van Ness,Ian B Stanaway,Theo K Bammler,James W MacDonald,Matthew R Thau,Jonathan Himmelfarb,
Journal of the American Society of Nephrologyno. 11S (2023): 118-118
PHARMACEUTICAL RESEARCHno. 11 (2023): 2597-2606
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