His research activities since 1980 have revolved around many aspects of RSV infection. These include characterizing the function and antigenic characteristics of the viral proteins, primarily the F and G glycoproteins. This work also involved study of their role as potential vaccines in animal models of RSV infection. Dr. Walsh's clinical research has centered on describing the epidemiology and clinical characteristics of RSV infection in adult populations with an emphasis on high risk and elderly populations. Laboratory work has attempted to describe immune correlates of protection in these groups. Currently, he is completing a three year study on the pathogenesis of disease severity in full term infants with primary RSV infection.