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In the early 20th century, hypertension was not considered a disease, but a normal part of aging. In fact, it was felt by the medical community that high blood pressure was a good thing, because it improved circulation. Even so, there was no reliable way to lower high blood pressure until the 1940s. But Freis's studies, first published in the New England Journal of Medicine in 1954 then later expanded in the 1960s, showed that hypertension actually increased the likelihood of stroke and heart attack. The 1960s study lasted five years (1964–1969), and was designed to determine whether treatment of hypertension would help prevent death and injury from complications due to stroke, kidney damage, congestive heart failure, and heart attack. The study found that treatment dramatically decreased the number of strokes, congestive heart failure, and kidney damage, but did not prevent heart attacks and sudden cardiac death. The study was one of the first randomized, double-blind, multi-institutional clinical trials ever done in the United States.
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Papers共 140 篇Author StatisticsCo-AuthorSimilar Experts
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II. DIHYDROERGOCORNINE,EDWARD D. FREIS,JOSEPH R. STANTON,JULIUS LITTER,JAMES W. CULBERTSON,MEYER H. HALPERIN,F. CORBIN MOISTER,ROBERT W. WILKINS
semanticscholar(2013)
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msra(2010)
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Egas Armelin, George Bousvaros,Eugene Braunwald,Charles A Chidsey,Edward D Freis,Thomas E Gaffney,Robert P Goldman,Donald C Harrison,Matthew Levy
Journal of The American Musicological Societyno. 3 (2010): 713-715
Acta Medica Scandinavicano. S576 (2009): 93-97
semanticscholar(2005)
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