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个人简介
Dr. Candelario-Jalil’s research interests have been fostered by many years of work in neuropharmacology, biochemistry, and molecular biology. Dr. Candelario-Jalil’s postdoctoral training in Germany and the United States focused upon elucidating the mechanisms underlying the neuroprotective ability of cyclooxygenase-2 (COX-2) inhibitors in experimental animal models of ischemic injury (focal ischemic stroke induced by middle cerebral artery occlusion and global forebrain ischemia). His current research activities are focused on identifying the downstream prostaglandin E2 (PGE2) receptors involved in ischemic brain injury and neuroinflammatory mechanisms responsible for the late opening of the blood-brain barrier following stroke. Other research areas in Dr. Candelario-Jalil’s laboratory include investigating neurovascular effects of adropin, a recently identified peptide, in animal models of ischemic stroke. Moreover, another main project involves the study of the role of bromodomain and extraterminal domain (BET) proteins in the neuroinflammatory response to ischemic stroke.
Dr. Candelario-Jalil directs an active research program with great translational potential, funded by two R01 grants from the NIH. Research is focused on understanding neuroinflammatory mechanisms following ischemic stroke utilizing biochemical, cellular, genetic, pharmacological, and MRI multimodal approaches. As encouraged by the NIH/NINDS Roadmap, this type of translational research is of fundamental importance in accelerating the development of effective stroke therapeutics.
Dr. Candelario-Jalil directs an active research program with great translational potential, funded by two R01 grants from the NIH. Research is focused on understanding neuroinflammatory mechanisms following ischemic stroke utilizing biochemical, cellular, genetic, pharmacological, and MRI multimodal approaches. As encouraged by the NIH/NINDS Roadmap, this type of translational research is of fundamental importance in accelerating the development of effective stroke therapeutics.
研究兴趣
论文共 142 篇作者统计合作学者相似作者
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Jonathan Larochelle, John Aaron Howell,Changjun Yang,Lei Liu,Rachel E. Gunraj, Sofia M. Stansbury, Antonio Carlos Pinheiro de Oliveira,Shairaz Baksh,Eduardo Candelario-Jalil
Experimental Neurologypp.114812-114812, (2024)
Frontiers in Stroke (2024)
Yong Ge,Changjun Yang,Mojgan Zadeh,Shane M. Sprague, Yang-Ding Lin,Heetanshi Sanjay Jain, Brenden Fitzgerald Determann,William H. Roth, Juan Pablo Palavicini,Jonathan Larochelle,Eduardo Candelario-Jalil,Mansour Mohamadzadeh
iScienceno. 4 (2024): 109480-109480
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Journal of neuroimmunology (2023): 578239-578239
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