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He researches the role of mitochondrial carrier proteins in the transport of metabolites, cofactors and ions across the mitochondrial inner membrane. The outer membrane of mitochondria is permeable for small molecules as it contains large pores, but the inner membrane, which forms cristae, is tightly sealed. A large number of different molecules need to traverse the inner membrane to link the biochemical pathways of the cytosol and mitochondria. Among these compounds are keto acids derived from sugars and fatty acids derived from fat, which are oxidised inside mitochondria to generate the cellular fuel ATP. Amino acids, derived from protein, also enter mitochondria, where they are broken down, interconverted, or used in protein synthesis. Many vitamins are required in the mitochondrial matrix as they act as co-factors for many mitochondrial enzymes. Finally, nucleotides, which are required for replication and transcription of mitochondrial DNA, also need to traverse the inner membrane. More than 60 different transport proteins are present in the mitochondrial inner membrane to facilitate the translocation of these compounds. They belong to different protein families, such as the ABC transporter family, the mitochondrial pyruvate carrier family, and the mitochondrial carrier family. The function of the vast majority of them has not been established. We are interested in studying their role in cellular metabolism and human physiology. We would also like to establish how they work in order to identify the molecular cause for the diseases that are associated with their dysfunction.
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Trends in Biochemical Sciences (2024)
Barbara Yu, Li Eon Kuek, Toni Vukovic,Georgios Makris,Jun Kido,Shirou Matsumoto,Kimitoshi Nakamura,Winifred Yau, Paul Yen, Luis Gonzalez-Moreno,Jorgina Satrustegui,Laura Contreras,
Molecular Genetics and Metabolismno. 4 (2024): 108274
biorxiv(2024)
British Journal of Pharmacologyno. S2 (2023): S374-S469
Archives of Biochemistry and Biophysics (2023): 109638-109638
Scott A. Jones, Prerana Gogoi,Jonathan J. Ruprecht,Martin S. King,Yang Lee,Thomas Zögg,Els Pardon,Deepak Chand,Stefan Steimle, Danielle M. Copeman,Camila A. Cotrim,Jan Steyaert,
Science Advancesno. 22 (2023)
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BRITISH JOURNAL OF PHARMACOLOGY (2023): S374-S469
Acta physiologica (Oxford, England)no. 4 (2023): e14016-e14016
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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