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Research Interests
My research focuses primarily on the development and application of novel mass spectrometry (MS) based techniques for metabolic phenotyping and on the fusion of mass spectrometric methods with chemometric analysis, which is currently a significant bottleneck in the analysis pipeline. Broadly, my research at Imperial College has involved the development, optimisation and application of UPLC-MS methodologies for the analysis of biological samples, largely in the context of metabolic phenotyping: serum, urine, tissue, amniotic fluid, and microdialysates. These developmental advances have resulted in shorter analysis times – and therefore higher sample throughput – key for large scale metabolic phenotyping studies. Peak detection and analytical reproducibility have been enhanced, improving metabolome coverage and the potential for biomarker identification and quantification.
I am applying these methods to biomedical research areas including toxicology, cardiovascular disease, neonatal disease and development, maternal exposures and effects on early childhood, and neurological diseases.
My research focuses primarily on the development and application of novel mass spectrometry (MS) based techniques for metabolic phenotyping and on the fusion of mass spectrometric methods with chemometric analysis, which is currently a significant bottleneck in the analysis pipeline. Broadly, my research at Imperial College has involved the development, optimisation and application of UPLC-MS methodologies for the analysis of biological samples, largely in the context of metabolic phenotyping: serum, urine, tissue, amniotic fluid, and microdialysates. These developmental advances have resulted in shorter analysis times – and therefore higher sample throughput – key for large scale metabolic phenotyping studies. Peak detection and analytical reproducibility have been enhanced, improving metabolome coverage and the potential for biomarker identification and quantification.
I am applying these methods to biomedical research areas including toxicology, cardiovascular disease, neonatal disease and development, maternal exposures and effects on early childhood, and neurological diseases.
研究兴趣
论文共 129 篇作者统计合作学者相似作者
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Neuro-Oncologyno. Supplement_3 (2023)
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Kidney International Reportsno. 6 (2023): 1231-1238
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Plinio Ferreira,Ricky Vaja, Maria Lopes-Pires,Marilena Crescente,He Yu,Rolf Nüsing,Bin Liu,Yingbi Zhou,Magdi Yaqoob,Anran Zhang,Matthew Rickman, Hilary Longhurst,
Kidney International Reports (2023)
Dominic Anthony Friston,Joshua Cuddihy, Jessica Souza Luiz,An Hoai Truong,Laptin Ho,Meirvaan Basra,Peter Santha,Orsolya Oszlacs,Joao de Sousa Valente,Tim Marczylo,Sini Junttila,Helen Laycock,
Plinio M. Ferreira,Nicholas Kirkby,Ricky Vaja, Maria Lopes Pires,Marilena Crescente, Bin Liu,He Yu,Melissa Chan, Rolf Nuesing, Yongbi Zhou, William White,Elizabeth Want,
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Maria Lopes Pires,Plinio Ferreira, Fisnik Shala, Neringa Cypaite, Maria Vinokurova,Elizabeth Want, Harvey Herschman,Jane A. Mitchell,Nicholas Kirkby
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Virag Sagi-Kiss, Yufeng Li,Matthew R Carey, Sarah J Grover,Karsten Siems,Francesca Cirulli,Alessandra Berry,Chiara Musillo,Ian D Wilson,Elizabeth J Want,Jacob G Bundy
Maria João Pires,Plinio Ferreira,Fisnik Shala,Neringa Cypaite,Maria Vinokurova,Elizabeth J. Want,Harvey R. Herschman,Jane A. Mitchell, Nicholas S. Kirkby
Circulationno. Suppl_1 (2022)
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