Dr. Marques is a researcher in the virology department at Fiocruz and has applied his career to vaccines, pre-clinical and clinical immunology, studying the immune responses to infections and/or vaccines in animal models, ex-vivo models and in clinical samples. In these studies, Dr. Marques has identified immune mechanisms associated with immunity and disease pathogenesis and this knowledge has been applied to the development of successful diagnostic tools that have been used in vaccinology and epidemiological surveys and vaccines that are being developed by the pharmaceutical industry. His main contributions are the development of molecular adjuvants for mRNA/DNA and vectored vaccines that enhances antigen presentation to CD4+ T-cells, the identification of the Zika outbreak in Recife, Brazil and the association of Zika infection with the microcephaly outbreak. Currently, he is working on Zika, Dengue, HIV and COVID-19 immune responses and vaccines.